Results 91 to 100 of about 1,314,183 (287)

Boron Concentration Induced Co-Ta-B Composite Formation Observed in the Transition from Metallic to Covalent Glasses

Condensed Matter, 2020
Due to their unique property combination of high strength and toughness, metallic glasses are promising materials for structural applications. As the behaviour of metallic glasses depends on the electronic structure which in turn is defined by chemical ...
Simon Evertz, Stephan Prünte, Lena Patterer, Amalraj Marshal, Damian M. Holzapfel, Alexander Schökel, Marcus Hans, Daniel Primetzhofer, Jochen M. Schneider   +8 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Oxytocin blocks pet dog (Canis familiaris) object choice task performance being predicted by owner-perceived intelligence and owner attachment

Pet Behaviour Science, 2016
A positive association has been found between owner-rated dog cognition and owner-perceived closeness to their dog, using the Perceptions of Dog Intelligence and Cognitive Skills (PoDIaCS) survey and the Monash Dog Owner Relationship Scale (MDORS ...
Jessica Lee Oliva, Jean-Loup Rault, Belinda Appleton, Alan Lill   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Validation Study of the Postpartum Bonding Questionnaire in Iranian Mothers [PDF]

مراقبت پرستاری و مامایی ابن سینا
Background and Objective: Postpartum bonding disorder is a significant impairment in the mother-infant relationship during the postpartum period. The present study aimed to translate and validate the Postpartum Bonding Questionnaire (PBQ) in Iranian ...
Abbas Ebadi, Fatemeh Ghavidel, Hamid Sharif Nia, Seyedeh Zahra aemmi   +3 more
doaj  

Antibacterial effect of the nanoparticle-incorporated primers commonly used for orthodontic bonding

Journal of Pharmacy and Bioallied Sciences
Background: Nanosized antibacterial agents can be used to prevent biofilm buildup on orthodontic appliances and auxiliaries, limiting microbial adherence and preventing caries.
Ekta Gupta, Tejas A Chaugule, Ajay K Kubavat, Preetham Ravuri, Katha Mandal, Praveen K Varma   +5 more
doaj   +1 more source

The influence of sociodemographic context on parent/baby bonding

INFAD, 2017
Background: The bonding process is essential to favors and/or determines the future relationship between parent and baby and influences the cognitive and social development of the child.
Carla Cruz, Paula Nelas, Emília Coutinho, Cláudia Chaves, Odete Amaral   +4 more
doaj   +1 more source

Gun facilitates adhesive bonding of studs to surfaces [PDF]

, 1969
Gun facilitates adhesive bonding of thermoplastic-backed studs to smooth, hard surfaces. Such studs can be used for mounting loads where defacement with drilled holes cannot be tolerated. These studs can be easily removed by softening the plastic bonding
Davis, B. K., Simpson, W. G.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source