Results 81 to 90 of about 1,310,092 (286)
El proyecto MUA resultó electo como propuesta ganadora en la categoría de Objeto Arquitectónico en el Primer Concurso de Diseño de Arquitectura organizado por la Asociación de Estudiantes de Arquitectura de la Universidad de Costa Rica (AEDA).
Leonardo Arguedas
doaj +1 more source
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Children’s Body Odors: Hints to the Development Status
Mothers can recognize their own children by body odor. Besides signaling familiarity, children’s body odors may provide other information relevant to maternal caregiving behavior, such as the child’s developmental status.
Laura Schäfer +4 more
doaj +1 more source
A structural, spectroscopic and theoretical study of the triphenylphosphine chalcogenide complexes of tungsten carbonyl, [W(XPPh3)(CO)5], X=O, S, Se [PDF]
The series [W(XPPh3)(CO)5], X=O, S, Se has been structurally determined by X-ray crystallography and fully characterised spectroscopically to provide data for comparing the bonding of the Ph3PX ligands to the metal.
Cook, Julian B. +2 more
core +2 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Abstract The advantages of indirect bonding have heen recognised for more than twenty years. However the technique has not gained widespread acceptance as an alternative to conventional direct honding. Reports of difficulty in achieving adequate isolation of posterior teeth and prohlems with resin flash and low hond strength may explain ...
openaire +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Acolhimento precoce e o vínculo na institucionalização
Este artigo propõe a análise das demandas psicológicas de três meninos, com idades entre 1 e 2 anos, abrigados em uma instituição localizada no estado do Rio Grande do Sul.
Gabriela Golin +1 more
doaj +1 more source
Due to their unique property combination of high strength and toughness, metallic glasses are promising materials for structural applications. As the behaviour of metallic glasses depends on the electronic structure which in turn is defined by chemical ...
Simon Evertz +8 more
doaj +1 more source

