Results 191 to 200 of about 2,349,577 (305)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Fluctuating β-Sheet Secondary Structure in DS119 Explains the Small Effects of Backbone N-Amination on Thermal Stability. [PDF]

J Pept Sci
Qiao Y, Starnes SK, Dolenc J, Del Valle JR, Smith LJ.   +4 more
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Covalency of M-N Bonds in Isomorphous Lanthanide and Actinide 5‑(2-Pyridyl)‑1<i>H</i>‑tetrazolate Complexes. [PDF]

JACS Au
Bai Z, Martelles MC, Gao Q, Beck NB, Brannon JP, Sperling JM, Albrecht TE.   +6 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Recent Advances in the High-Value Conversion of Alkenes Induced by Electrochemistry. [PDF]

Molecules
Liang X, Wang H, Xie W, Liu Z, Qin D.
europepmc   +1 more source

Catastrophe Bonds

Barrieu, Pauline, Braun, Alexander, Makariou, Despoina   +2 more
openaire   +2 more sources

Chemical Bonding [PDF]

Annual Review of Physical Chemistry, 1978
openaire   +2 more sources

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Theoretical insights into the stability and nature of nonconventional C-H⋯Y (Y[double bond, length as m-dash]N, P, As, Sb) hydrogen bonds in haloform-pnictogen trihydride complexes. [PDF]

RSC Adv
Pham KN, Anh Thu DT, Ai BD, Trung NT.
europepmc   +1 more source