Results 111 to 120 of about 336,536 (219)

Neuro-skeletal units and Smart Analgesia: reprogramming sensory neurons for fracture repair. [PDF]

Mil Med Res
Bai L, Su JC.
europepmc   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Correction: Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024

Frontiers in Oncology
Yanhong Pei, Haijie Liang, Yu Guo, Boyang Wang, Han Wu, Zhijian Jin, Shanyi Lin, Fanwei Zeng, Yifan Wu, Qianyu Shi, Jiuhui Xu, Yi Huang, Tingting Ren, Jiarui Liu, Jiarui Liu, Wei Guo   +15 more
doaj   +1 more source

Blocking interaction of sclerostin loop3 with osteoblastic LRP4 counteracts bone loss without increasing arterial stiffness during mechanical unloading. [PDF]

J Orthop Translat
Wang L, Zhang N, Jiang H, Tao X, Ma Y, Hu Z, Zhong C, Yang X, Yu S, Zhang H, Liu J, Yu Y, Liu F, Chen Z, Luo H, Ding S, Zhang Y, Sun M, Zhang S, Ferdinandy P, Yu R, Zhang T, Lu A, Qin L, Zhang S, Zhang B, Zhang G.   +26 more
europepmc   +1 more source

Macrophage‐to‐Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK‐SPP1‐SRC‐TKS5 Signaling Axis

Advanced Science, EarlyView.
MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Yungeng Wei, Hua Guo, Xiangsheng Yang, Xiao Xiao Tang   +3 more
wiley   +1 more source

A motion-activated skeletal "Pacemaker" for systemic bone remodeling via oral piezoelectric microspheres. [PDF]

Bioact Mater
Han W, Luo J, Xu Y, He X, Li X, Tan J, Wang Z, He Y, Zou P, Peng Y, Han X, Bai D, Shen J.   +12 more
europepmc   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Directing Neutrophil Fate via Sensory-Immune Interactions Accelerates Diabetic Bone Healing. [PDF]

Research (Wash D C)
Qi X, Huang Y, Li Y, Chen J, Zhou M, Mei L, Xu Z, Lin S, Jiang X.   +8 more
europepmc   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Metformin attenuates diabetic osteoporosis via the miR-21 mediated Mef2c/Sost pathway. [PDF]

Front Endocrinol (Lausanne)
Liu L, Xu J, Zheng H, Li XC, Gao ZA, Meng C, Pan C, Yang JH, Chang BC.   +8 more
europepmc   +1 more source