Results 241 to 250 of about 588,712 (307)

Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity

Advanced Science, EarlyView.
In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin, Lu‐Jun Zhou, Hui‐Lin Ye, Ting Liu, Bo‐Yan Chen, Xue‐Bing Bai, Jun Zhang, Lan Bai, Lin‐Juan Du, Yuan Liu, Yong‐Li Wang, Hong Zhu, Yu‐Lin Li, Shuo Xu, Xiao‐Qian Meng, Guo‐Cai Tian, Yan Liu, Wu‐Chang Zhang, Ya‐Qin Zhu, Sheng‐Zhong Duan   +19 more
wiley   +1 more source

Phosphatidylinositol-3-kinase/protein kinase B signaling dysregulation in steroid-induced osteonecrosis of the femoral head: A minireview of therapeutic implications. [PDF]

World J Orthop
Wang YN, Jiang JX, Pang CX, Sun L, Sun R, Wang FM, Jiang HJ.   +6 more
europepmc   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Gram‐Scale Synthesis of Hafnium‐Rich Carbon Dots for Preclinical Computed Tomography Imaging Across Various Systems

Advanced Science, EarlyView.
Hafnium (Hf)‐rich carbon dots (Hf‐rCDs) with high metal content (40.7%) and robust batch production capacity (>2 g per batch) are synthesized via a facile air‐assisted pyrolysis method. In vivo CT imaging demonstrates outstanding performance of Hf‐rCDs across multiple physiological systems and enables high‐resolution visualization of swine cervical ...
Shuo Li, Hengrui Wu, Jianqi Deng, Qiyu Sun, Yuping Zhang, Cai Zhang, Jinbin Pan, Dingbin Liu, Xuejun Zhang, Quan Zou, Xiaoyuan Chen, Shao‐Kai Sun   +11 more
wiley   +1 more source

Schwann cell-derived extracellular vesicles inhibit osteoclastogenesis through the PTEN/AKT axis in peripheral nerve-bone crosstalk. [PDF]

J Nanobiotechnology
Yang H, Yu B, Li R, Hong Y, Shen M, Shen T, Wang X, Liu H, Wang G, Xu K, Ma Y, Li M, Su J.   +12 more
europepmc   +1 more source

Implantation awakens peri-implant osteogenic potential via Snx5-EGFR axis-mediated mechanical transduction. [PDF]

Int J Oral Sci
Jiang X, Weng Y, Feng Y, Huang J, Wang H, Wang Z.   +5 more
europepmc   +1 more source

Biomimetic <i>de novo</i> construction of hierarchically aligned and gradient-mineralized collagen for tendon-bone integrated regeneration. [PDF]

Bioact Mater
Lei M, Luo H, Sun L, Shi S, Zhang Z, Yu C, Gao H, Chen J, Liu C, Qu X.   +9 more
europepmc   +1 more source

Effects of Glucagon-Like Peptide-1 Receptor Agonist on Bone Metabolism and the Expression of Insulin Receptor Substrate 1 in an Osteoporotic Rat Model. [PDF]

Int J Endocrinol
Ye Y, He YL, He J, Yang DY, Xia N.
europepmc   +1 more source

Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis. [PDF]

Bone Res
Dou C, Dan Y, Zhang Z, Li X, Qu Y, Wu Y, Zhang Z, Guo S, Xu J, Luo F.   +9 more
europepmc   +1 more source