Results 21 to 30 of about 336,536 (219)

Comparison of Individual Tissue-Engineered Bones and Allogeneic Bone in Treating Bone Defects: A Long-Term Follow-Up Study

Cell Transplantation, 2020
The treatment of bone defects has always been a challenge for orthopedic surgeons. The development of tissue engineering technology provides a novel method for repairing bone defects and has been used in animal experiments and clinical trials.
Peng Yang, Jiangling Zhou, Qiuchi Ai, Bo Yu, Moyuan Deng, Fei Luo, Zhao Xie, Junchao Xing, Tianyong Hou   +8 more
doaj   +1 more source

Novel mutations in BMP1 result in a patient with autosomal recessive osteogenesis imperfecta

Molecular Genetics & Genomic Medicine, 2021
Background Osteogenesis imperfecta (OI) is a rare heritable bone disorder that is characterised by increased bone fragility and recurrent fractures. To date, only 19 OI patients have been reported, as caused by BMP1 gene mutations, worldwide.
Lei Xi, Shanshan Lv, Hao Zhang, Zhen‐Lin Zhang   +3 more
doaj   +1 more source

Analysis benefits of a second Allo-HSCT after CAR-T cell therapy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia who relapsed after transplant

Frontiers in Immunology, 2023
BackgroundChimeric antigen receptor (CAR) T-cell therapy has demonstrated high initial complete remission (CR) rates in B-cell acute lymphoblastic leukemia (B-ALL) patients, including those who relapsed after transplant.
Xing-yu Cao, Jian-ping Zhang, Yan-li Zhao, Min Xiong, Jia-rui Zhou, Yue Lu, Rui-juan Sun, Zhi-jie Wei, De-yan Liu, Xian Zhang, Jun-fang Yang, Peihua Lu, Peihua Lu   +12 more
doaj   +1 more source

Myeloma-derived IL-32γ induced PD-L1 expression in macrophages facilitates immune escape via the PFKFB3-JAK1 axis

OncoImmunology, 2022
Multiple myeloma (MM) is characterized by an accumulation of monoclonal plasma cells within the bone marrow (BM). Macrophages are an abundant component of myeloma BM microenvironment and support survival of the malignant cells and foster myeloma ...
Yang Liu, Haimeng Yan, Huiyao Gu, Enfan Zhang, Jingsong He, Wen Cao, Jianwei Qu, Ruyi Xu, Liqin Cao, Donghua He, Jinna Zhang, Yifan Hou, Zhen Cai   +12 more
doaj   +1 more source

Efficacy Analysis of Selection of Distal Reference Point for Tibial Coronal Plane Osteotomy during Total Knee Arthroplasty: A Literature Review

Orthopaedic Surgery, 2021
Total knee arthroplasty is an effective treatment for end‐stage knee osteoarthritis. The tibial platform osteotomy must take full account of the coronal plane, the sagittal plane, and the rotational alignment of the tibial prosthesis.
Jie Men, Han‐guang Liang, Zhi‐wei Wang, Peng Sun, Wei Feng   +4 more
doaj   +1 more source

Tibial cortex transverse transport facilitating healing in patients with recalcitrant non-diabetic leg ulcers

Journal of Orthopaedic Translation, 2021
Summary: Objective: The treatment of recalcitrant not-diabetic leg ulcers remains challenging. Distraction osteogenesis is accompanying by angiogenesis and neovascularization in the surrounding tissues.
Xinyu Nie, Xiaocong Kuang, Guangwei Liu, Zhaowei Zhong, Yi Ding, Jie Yu, Jie Liu, Shanlang Li, Liexun He, Hongjie Su, Wencong Qin, Jinmin Zhao, Qikai Hua, Yan Chen   +13 more
doaj   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

High serum IL-17A is associated with bone destruction in newly diagnosed multiple myeloma patients

Frontiers in Oncology, 2022
BackgroundMultiple myeloma (MM) is a malignant proliferative disease of the blood system, characterized by the abnormal growth of clonal plasma cells in the bone marrow.
Mengmeng Dong, Jinna Zhang, Qingxiao Chen, Donghua He, Haimeng Yan, Gaofeng Zheng, Xiaoyan Han, Jingsong He, Zhen Cai, Zhen Cai   +9 more
doaj   +1 more source

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source

Clinical characteristics of 10 Chinese patients with melorheostosis and identification of a somatic MAP2K1 variant in one case

Molecular Genetics & Genomic Medicine, 2022
Background Melorheostosis (MEL) is an exceptionally rare sclerosing bone dysplasia with asymmetrically exuberant bone formation and soft tissue lesions in a segmental distribution.
Xiaojun Han, Yang Xu, Zhanying Wei, Chun Wang, Hua Yue, Zhenlin Zhang   +5 more
doaj   +1 more source