Results 71 to 80 of about 336,536 (219)

Research progress in the application of single‐cell sequencing technology in rheumatic diseases

Rheumatology & Autoimmunity
Rheumatic diseases, such as rheumatoid arthritis and systemic lupus erythematosus, represent a complex and heterogeneous group of immune‐mediated disorders.
Xinzhe Feng, Zhou Ji, Changhao Han, Zhi Li, Chenxu Liu, Weidong Xu   +5 more
doaj   +1 more source

Atlas of Fshr expression from novel reporter mice

eLife
The FSH-FSHR pathway has been considered an essential regulator in reproductive development and fertility. But there has been emerging evidence of FSHR expression in extragonadal organs.
Hongqian Chen, Hui-Qing Fang, Jin-Tao Liu, Shi-Yu Chang, Li-Ben Cheng, Ming-Xin Sun, Jian-Rui Feng, Ze-Min Liu, Yong-Hong Zhang, Clifford J Rosen, Peng Liu   +10 more
doaj   +1 more source

Robotic Control for Human–Robot Collaborative Assembly Based on Digital Human Model and Reinforcement Learning

Advanced Robotics Research, EarlyView.
This work presents a robotic control method for human–robot collaborative assembly based on a biomechanics‐constrained digital human model. Reinforcement learning is used to generate physiologically plausible human motion trajectories, which are integrated into a virtual environment for robot control learning.
Bitao Yao, Hongzhou Ai, Wenjun Xu, Zude Zhou, Lihui Wang   +4 more
wiley   +1 more source

Identifying risk factors for severe omicron infection in allogeneic hematopoietic stem cell transplant recipients with hematologic malignancies

Cancer Reports
Background In December 2022, a large‐scale epidemic occurred in China due to Omicron variant of SARS‐CoV‐2. This study explored risk factors for Omicron infection in transplant recipients at our institution and investigated the factors influencing the ...
Zhihui Li, Lei Wang, Qinlong Zheng, Teng Xu, Keyan Yang, Xianxuan Wang, Xiaopei Wen, Caiyan Zhang, Jingjing Wang, Yanzhi Song, Yongqiang Zhao, Xiaoyu Zheng, Tong Wu   +12 more
doaj   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Bioinspired Soft‐Skeleton Robotics With Cooperative Shape Transformation and Stiffness Adaptation

Advanced Robotics Research, EarlyView.
A bioinspired soft‐skeleton robot that integrates variable‐stiffness chain skeletons into a soft textile skin is developed. The chain skeletons are highly flexible initially but can stiffen upon pneumatic actuation, enabling large deformation and enhanced load‐bearing capacity.
Mengyuan Niu, Xiaorui Hu, Chenmin Yuan, Haoyun Li, Xuzhong Su, Fengxin Sun   +5 more
wiley   +1 more source

Effect of Palygorskite on the Sintering Process and Kinetics of Bone China. [PDF]

ACS Omega, 2020
Zhang Y, Wang L, Sun J, Zhang Y, Wang K, Tian L, Liang J.   +6 more
europepmc   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source