Results 171 to 180 of about 103,589 (360)

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

open access: yesAdvanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei   +10 more
wiley   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

open access: yesAdvanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir   +7 more
wiley   +1 more source

264 Determinants of bone loss in cystic fibrosis

open access: bronze, 2013
D. Gensburger   +4 more
openalex   +1 more source

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui   +18 more
wiley   +1 more source

Solitary Bone Cyst: A Case Report and Review of Literature

open access: yesJournal of Indian Academy of Oral Medicine and Radiology, 2010
Solitary bone cyst (SEC) is a rare disorder of the jaw bones, as well as other skeletal bones, particularly the long bones. It usually occurs in the metaphyseal region of long bones comprising only around 2% of all bone cysts affecting this area ...
Ajay R Bhoosreddy   +3 more
doaj  

Aneurysmal Bone Cysts Recur at Juxtaphyseal Locations in Skeletally Immature Patients

open access: green, 2008
Patrick P. Lin   +4 more
openalex   +2 more sources

Single‐Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics

open access: yesAdvanced Science, EarlyView.
A novel amino acid (aa)‐score‐based single‐position peptide clustering strategy is developed for peptidomics, enabling precise profiling of protein proteolysis in plasma from β‐thalassemia cohort. The method identifies new aa position‐based peptide cluster biomarkers validated by heavy‐labeled peptides, visualizes aggregated changes, uncovers disease ...
Na Li   +13 more
wiley   +1 more source

Aneurysmal bone cyst of rib presenting as a huge chest wall mass

open access: yesThe Turkish Journal of Pediatrics, 2009
Aneurysmal bone cyst is a rare benign tumor of the bone that can be difficult to distinguish from malignant tumors, especially when it presents in an unusual location. Herein, we report a six-year-old girl with a primary aneurysmal bone cyst in an
Dilek Güneş   +4 more
doaj  

WS06.5 New insights into the pathogenesis and potential therapies of cystic fibrosis (CF) bone disease

open access: bronze, 2016
Frédéric Velard   +9 more
openalex   +1 more source

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