Results 171 to 180 of about 53,728 (264)

Agropastoral possibilism and the trajectorial affordances of Danish inland heaths: a study of deep‐time entrapment Possibilisme agropastoral et affordances des trajectoires dans les landes de l'arrière‐pays danois : une étude des entraves dans le passé lointain

Journal of the Royal Anthropological Institute, EarlyView.
History does not unfold along a single trajectory, and yet the socioecological configuration of landscapes may narrow the directions history can take. This article develops a framework for assessing the directionality of history in a (pre)historic heath landscape in Denmark.
Zachary Caple, Mette Løvschal
wiley   +1 more source

Novel drug targets for monkeypox: From viral to host proteins. [PDF]

Infect Med (Beijing)
Zhu Z, Sun Q, Xu Y, Niu Y, Yang F, Feng S.   +5 more
europepmc   +1 more source

Ancient and historical systems [PDF]

, 2009
Adriaens, Mieke, Bertrand, Loic, Dillmann, Philippe, Dowsett, Mark   +3 more
core   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Aging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla, Veronica Barbi, Antonello Mai, Clemens Zwergel, Serena Marcozzi, Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Fiorenza Orlando, Robertina Giacconi, Fabrizia Lattanzio, Giulia Matacchione, Chiara Giordani, Massimo Bracci, Fabiola Olivieri, Federico Boschi, Paola Tabarelli De Fatis, Giovanni Battista Ivaldi, Marco Malavolta, Antonella Farsetti, Maria Cristina De Rosa, Carlo Gaetano   +24 more
wiley   +1 more source

Long-Term Denosumab Treatment in Adults with Juvenile Paget Disease. [PDF]

Calcif Tissue Int
Polyzos SA, Anastasilakis K, Cundy T, Kita M.   +3 more
europepmc   +1 more source

Integrating Sr isotopes, microchemistry, and genetics to reconstruct Salmonidae species and life history

Archaeometry, EarlyView.
Abstract Recent approaches to fisheries research emphasize the importance of the coproduction of knowledge in building resilient and culturally mindful fisheries management frameworks. Despite widespread recognition of the need for Indigenous knowledge and historical reference points as baseline data, archaeological data are rarely included in ...
Ross Salerno, Remi Murdoch, Joanna Elmore, Taylor Wilcox, Jens Hegg, Catherine S. Austin, Michael LeMoine, Jade Luckhurst, Alexandra K. Fraik, Molly Carney   +9 more
wiley   +1 more source

Bone Health Management in Men Commencing Androgen Deprivation Therapy for Prostate Cancer and Women Commencing Anti-Oestrogen Therapy for Breast Cancer. [PDF]

Cancer Med
Liang I, Brennan S, Girgis C, Hayden A, Moujaber T, Turner S, Vasista A, Grossmann M, Wong PKK.   +8 more
europepmc   +1 more source

Interplay between inflammatory reflex and energetic metabolism in endotoxaemia: A role for haem oxygenase 1?

British Journal of Pharmacology, EarlyView.
Inflammation is vital for defence against injury and infection, but excessive inflammation can lead to tissue damage and disease. The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic–pituitary–adrenal axis and the anti‐inflammatory reflex, which limit systemic inflammation.
Evelin C. Cárnio, Luiz G. S. Branco, Fernanda Brognara, Patrícia Passaglia, Roberta Foresti, Roberto Motterlini   +5 more
wiley   +1 more source

RANKL Drives Bone Metastasis in Mammary Cancer: Protective Effects of Anti-Resorptive Treatments. [PDF]

Int J Mol Sci
Gkikopoulou E, Syrigos CC, Mantogiannakou I, Petraki CE, Stathopoulou M, Dragolia M, Rinotas V, Ntafis V, Rauner M, Douni E.   +9 more
europepmc   +1 more source

Beyond synapses: cytoplasmic connections in brain function and evolution

Biological Reviews, EarlyView.
ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley   +1 more source