Results 71 to 80 of about 55,987 (284)
Advanced Sustainable Systems, EarlyView.The shift to biodegradable materials in healthcare promises reduced plastic pollution, but their production, adoption, and long‐term impacts remain complex. Integrating lifecycle insights with global policy coordination is essential for meaningful environmental gains. Abstract The COVID‐19 pandemic sharply increased medical waste, intensifying concerns
By Haoxuan Yu +2 more
wiley +1 more source
Canadian Medical Association Journal, 2008 Background: Measurement of bone mineral density is the most common method of diagnosing and assessing osteoporosis. We sought to estimate the average rate of change in bone mineral density as a function of age among Canadians aged 25–85, stratified by ...
C. Berger +8 more
semanticscholar +1 more source
Merging Wildlife and Environmental Monitoring Approaches with Forensic Principles: Application of Unconventional and Non-Invasive Sampling in Eco-Pharmacovigilance [PDF]
, 2014 Pharmaceutical residues in the environment have the potential to harm wildlife. A population’s fragility or an animal’s secretive nature may preclude capture and the use of invasive/destructive sampling techniques that are typically used in a risk ...
Dowling, Geraldine +7 more
core +2 more sources
Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy
Advanced Science, EarlyView.Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao +8 more
wiley +1 more source
Common Medieval Pigments [PDF]
, 2004 This paper discusses the pigments used in medieval manuscripts. Specific types of pigments that are examined are earths, minerals, manufactured, and organics.
Baker, A
core +1 more source
Advanced Science, EarlyView.The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin +9 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen +14 more
wiley +1 more source
Multicellular Tumor Spheroid in an off-lattice Voronoi/Delaunay cell model
, 2005 We study multicellular tumor spheroids by introducing a new three-dimensional agent-based Voronoi/Delaunay hybrid model. In this model, the cell shape varies from spherical in thin solution to convex polyhedral in dense tissues. The next neighbors of the
Meyer-Hermann, Michael, Schaller, Gernot
core +1 more source