Results 101 to 110 of about 12,182,524 (404)

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Change in body temperature, not acute-phase reaction, predict anti-Osteoporosis efficacy after the first administration of Zoledronic acid: a prospective observational cohort study

BMC Musculoskeletal Disorders
Background Acute-phase reactions (APRs) are common among people treated for the first time with zoledronate (ZOL). The current view is that both the APRs caused by ZOL and its efficacy are related to the mevalonic acid pathway.
Yanping Du, Weijia Yu, Haixin Gou, Yiming Lei, Tongkai Zhang, Wenjing Tang, Minmin Chen, Huilin Li, Qun Cheng   +8 more
doaj   +1 more source

Identification of proteins found to be significantly altered when comparing the serum proteome from Multiple Myeloma patients with varying degrees of bone disease [PDF]

, 2014
Background: Bone destruction is a feature of multiple myeloma, characterised by osteolytic bone destruction due to increased osteoclast activity and suppressed or absent osteoblast activity.
Anderson, Kenneth C, Clarke, Colin, Clynes, Martin, Dowling, Paul, Hameed, Abdul, Hayes, Catriona, Meiller, Justine, Mitsiades, Constantine, O’Gorman, Peter, Richardson, Paul, Ting, Kay Reen   +10 more
core   +2 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

The vitamin D status in a Chinese osteogenesis imperfecta population and its correlation with bone metabolic markers and bone density

Frontiers in Nutrition
ObjectiveStudies on the baseline vitamin D levels in osteogenesis imperfecta (OI) patients before medication are scarce. This study assessed the vitamin D status of a population with OI at both the overall level and within different age groups.
Yunyi Jiang, Yazhao Mei, Yuan Tian, Li Shen, Shuqin Xu, Hao Zhang, Zhenlin Zhang   +6 more
doaj   +1 more source

Peripheral Blood Stem Cell Harvest HPC Count Is an Effective Surrogate Marker for CD34+ Cell Count in Allogeneic Stem Cell Transplant Setting

Translational Oncology, 2020
OBJECTIVE: We assessed the predictive potential of XN-HPC for CD34+ cell count as obtained through Sysmex automated hematology analyzers (XN-1000).
Aisha Jamal, Mohammad Tahir Khan, Sadia Parveen, Qurratulain Rizvi, Tasneem Farzana, Uzma Zaidi, Munira Borhany, Saima Siddiqui, Saqib Hussain Ansari, Tahir Sultan Shamsi   +9 more
doaj   +1 more source

Rheumatoid arthritis [PDF]

, 2016
Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability. Early diagnosis is key to optimal therapeutic success, particularly in patients with well-characterised risk factors for poor ...
Aletaha, Daniel, McInnes, Iain B., Smolen, Josef S.   +2 more
core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Pre-operative prognostic nutritional index was associated with recurrence after surgery in giant cell tumor of bone patients

Journal of Bone Oncology, 2020
Objectives: Giant cell tumors of bone (GCT) are benign with a local recurrence rate of approximately 20–50%. Growing evidence suggests that inflammation plays an important role in tumor formation and progression.
Shoulei Liang, Yong Li, Hongtao Liu, Baocang Wang   +3 more
doaj   +1 more source

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis [PDF]

, 2017
Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5(+) B lymphocytes in blood, bone marrow and lymphoid organs. CD1d-restricted invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in
Azzimonti, Laura, Bellone, Matteo, Bertilaccio, Maria Teresa, Caligaris Cappio, Federico, Capri, Miriam, Casorati, Giulia, de Lalla, Claudia, Delfanti, Gloria, Dellabona, Paolo, DI NAPOLI, Arianna, Doglioni, Claudio, Franceschi, Claudio, Ghia, Paolo, Gorini, Francesca, Gulino, Alessandro, Ranghetti, Pamela, Scarfò, Lydia, Scielzo, Cristina   +17 more
core   +1 more source