Results 121 to 130 of about 12,182,524 (404)

Animal models for bone tissue engineering and modelling disease

Disease Models & Mechanisms, 2018
Tissue engineering and its clinical application, regenerative medicine, are instructing multiple approaches to aid in replacing bone loss after defects caused by trauma or cancer.
J. McGovern, M. Griffin, D. Hutmacher
semanticscholar   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Presenting signs and patient co-variables in Gaucher disease : outcome of the Gaucher Earlier Diagnosis Consensus (GED-C) Delphi initiative [PDF]

, 2019
© 2018 The Authors. Internal Medicine Journal by Wiley Publishing Asia Pty Ltd on behalf of Royal Australasian College of Physicians.Background: Gaucher disease (GD) presents with a range of signs and symptoms.
Belmatoug , N, Bembi , B, Bright, J, Deodato, F, Di Rocco, M, Goker-Alpan, O, Hughes, DA, Kuter, David, Lukina, EA, Machaczka, M, Mehta, Atul, Mengel, E, Nagral, A, Nakamura, K, Narita, A, Oliveri , B, Pastores, G, Pérez-López, J, Ramaswami, U, Salek, Mir-Saeed Shayegan, Schwartz, IV, Szer, J, Vom Dahl, S, Weinreb, NJ, Zimran, A   +24 more
core   +6 more sources

Bone Disease in Multiple Myeloma: Pathophysiology and Management

Cancer Growth and Metastasis, 2014
Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM). More than 80% of MM patients suffer from destructive bony lesions, leading to pain, fractures, mobility issues, and neurological deficits.
A. Hameed, J. Brady, P. Dowling, M. Clynes, P. O’gorman   +4 more
semanticscholar   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Impacts of Prior Anti-Osteoporosis Treatments on Sequential Denosumab Responses in BMD Changes Among Postmenopausal Osteoporosis Women in East China: Real-World Data Analysis

Clinical Interventions in Aging
Guoyu Guan,1 Yanping Du,2,* Wenjing Tang,2 Minmin Chen,2 Weijia Yu,2 Huilin Li,2 Qun Cheng2,* 1Department of Geriatrics, Huadong Hospital, Fudan University, Shanghai, People’s Republic of China; 2Department of Osteoporosis and Bone ...
Guan G, Du Y, Tang W, Chen M, Yu W, Li H, Cheng Q   +6 more
doaj  

A rare incidence of severe dermatological toxicities triggered by concomitant administration of all-trans retinoic acid and triazole antifungal in patients with acute promyelocytic leukemia: a case series and review of the literature

Journal of Medical Case Reports
Background All-trans retinoic acid (ATRA) is an indispensable part of the treatment of acute promyelocytic leukemia (APL). Although, mild cutaneous toxicities like mucocutaneous xerosis, rash, and pruritus are well reported, ATRA associated severe ...
Aisha Jamal, Rafia Hassam, Qurratulain Rizvi, Ali Saleem, Anum Khalid, Nida Anwar   +5 more
doaj   +1 more source

Use of percutaneous core needle biopsy for diagnosing acral bone tumors

Journal of Bone Oncology, 2017
This study aims to evaluate the diagnostic value of percutaneous core needle biopsy (PCNB) in diagnosing acral bone tumors. The clinical PCNB data of 341 patients with bone tumors were retrospectively analyzed.
Zhichao Tong, Mingyu Zhang, Bo Chen, Yujie Zhu, Jianfeng Wei, Xiaoju Li   +5 more
doaj   +1 more source

Multiple Myeloma : an update on disease biology and therapy [PDF]

, 2004
Multiple myeloma is a malignancy of immunoglobulin producing plasma cells. Clinical features include bone pain due to lytic bone lesions or pathological fractures, anemia, symptomatic hypercalcemia, renal insufficiency, recurrent infections and ...
Cook, Rachel J., Dingli, David
core  

Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis [PDF]

, 2006
BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration ...
Ale Algra, Anne-Margriet Huisman, Ans C.M. Oostveen, Ben A.C. Dijkmans, Chris E.D. de Laet, de Nijs RN, Erik Buskens, George A.W. Bruyn, Johannes W.G. Jacobs, Johannes W.J. Bijlsma, Michel BA, Piet P.M.M. Geusens, Roland F.J. Laan, Ron N.J. de Nijs, Willem F. Lems   +14 more
core   +4 more sources