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Calcified Tissue International, 2019
Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by increased osteoclast-mediated bone resorption and a subsequent compensatory increase in bone formation, resulting in a disorganized mosaic of woven and lamellar bone at one or more affected skeletal sites.
Daniela Merlotti +4 more
openaire +6 more sources
Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by increased osteoclast-mediated bone resorption and a subsequent compensatory increase in bone formation, resulting in a disorganized mosaic of woven and lamellar bone at one or more affected skeletal sites.
Daniela Merlotti +4 more
openaire +6 more sources
Current Osteoporosis Reports, 2017
Bone disease is a defining characteristic of multiple myeloma (MM) and the major cause of morbidity. It manifests as lytic lesions or osteopenia and is often associated with severe pain, pathological fracture, spinal cord compression, vertebral collapse, and hypercalcemia.
Cristina Panaroni, A. Yee, N. Raje
semanticscholar +4 more sources
Bone disease is a defining characteristic of multiple myeloma (MM) and the major cause of morbidity. It manifests as lytic lesions or osteopenia and is often associated with severe pain, pathological fracture, spinal cord compression, vertebral collapse, and hypercalcemia.
Cristina Panaroni, A. Yee, N. Raje
semanticscholar +4 more sources
Endocrinology and Metabolism Clinics of North America, 2015
Pituitary hormones have direct and indirect effects on bone remodeling, and skeletal fragility is a frequent complication of pituitary diseases. Fragility fractures may occur in many patients with prolactinomas, acromegaly, Cushing disease, and hypopituitarism.
MAZZIOTTI, Gherardo +2 more
openaire +5 more sources
Pituitary hormones have direct and indirect effects on bone remodeling, and skeletal fragility is a frequent complication of pituitary diseases. Fragility fractures may occur in many patients with prolactinomas, acromegaly, Cushing disease, and hypopituitarism.
MAZZIOTTI, Gherardo +2 more
openaire +5 more sources
Orthopedic Clinics of North America, 1990
Paget's disease of bone is defined as a process of increased bone remodeling; the primary event is increased resorption (osteoclastic activity) followed by subsequent reactive bone formation (osteoblastic activity). It is usually asymmetric and may be asymptomatic.
Joseph M. Lane +2 more
openaire +3 more sources
Paget's disease of bone is defined as a process of increased bone remodeling; the primary event is increased resorption (osteoclastic activity) followed by subsequent reactive bone formation (osteoblastic activity). It is usually asymmetric and may be asymptomatic.
Joseph M. Lane +2 more
openaire +3 more sources
Best Practice & Research Clinical Haematology, 2004 The major clinical manifestation of multiple myeloma is related to the osteolytic bone destruction. The bone disease can lead to pathologic fractures, spinal cord compression, hypercalcemia, and pain. It is also a major cause of morbidity and mortality in these patients.
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Best Practice & Research Clinical Endocrinology & Metabolism, 2018
Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to ...
Appelman-Dijkstra, N.M. +1 more
openaire +4 more sources
Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to ...
Appelman-Dijkstra, N.M. +1 more
openaire +4 more sources
Vivas for the Oral and Maxillofacial Surgery FRCS, 2019
This chapter contains eight clinical vivas on the subject of maxillofacial bone disease. This will provide candidates sitting the vivas component of the Oral and Maxillofacial Surgery FRCS examination with practical knowledge in the assessment and ...
J. Breeze, Sat Parmer, N. McLeod
semanticscholar +1 more source
This chapter contains eight clinical vivas on the subject of maxillofacial bone disease. This will provide candidates sitting the vivas component of the Oral and Maxillofacial Surgery FRCS examination with practical knowledge in the assessment and ...
J. Breeze, Sat Parmer, N. McLeod
semanticscholar +1 more source
Immunology and Allergy Clinics of North America, 2018
Systemic mastocytosis can give very different bone pictures: from osteosclerosis to osteoporosis. Osteoporosis is one of the most frequent manifestations particularly in adults and the most clinical relevant. It is often complicated by a high recurrence of mainly vertebral fragility fractures.
Orsolini, Giovanni +4 more
openaire +4 more sources
Systemic mastocytosis can give very different bone pictures: from osteosclerosis to osteoporosis. Osteoporosis is one of the most frequent manifestations particularly in adults and the most clinical relevant. It is often complicated by a high recurrence of mainly vertebral fragility fractures.
Orsolini, Giovanni +4 more
openaire +4 more sources
Seminars in Hematology, 2001
Bone destruction is a hallmark of myeloma, with 70% to 80% of patients manifesting bone involvement. Destruction is mediated through normal osteoclasts (OCLs), which respond to local osteoclast-activating factors (OAFs) produced by myeloma cells or by other cells in the local microenvironment.
Natalie S. Callander +3 more
openaire +2 more sources
Bone destruction is a hallmark of myeloma, with 70% to 80% of patients manifesting bone involvement. Destruction is mediated through normal osteoclasts (OCLs), which respond to local osteoclast-activating factors (OAFs) produced by myeloma cells or by other cells in the local microenvironment.
Natalie S. Callander +3 more
openaire +2 more sources
Osteoporosis International, 2016
MicroRNAs are small, noncoding single-stranded RNAs that have emerged as important posttranscriptional regulators of gene expression, with an essential role in vertebrate development and different biological processes. This review highlights the recent advances in the function of miRNAs and their roles in bone remodeling and bone diseases.
GENNARI, LUIGI +2 more
openaire +5 more sources
MicroRNAs are small, noncoding single-stranded RNAs that have emerged as important posttranscriptional regulators of gene expression, with an essential role in vertebrate development and different biological processes. This review highlights the recent advances in the function of miRNAs and their roles in bone remodeling and bone diseases.
GENNARI, LUIGI +2 more
openaire +5 more sources