Results 81 to 90 of about 1,970,077 (362)

Osteogenesis imperfecta: potential therapeutic approaches [PDF]

PeerJ, 2018
Osteogenesis imperfecta (OI) is a genetic disorder that is usually caused by disturbed production of collagen type I. Depending on its severity in the patient, this disorder may create difficulties and challenges for the dental practitioner.
Maxime Rousseau, Jean-Marc Retrouvey, Members of the Brittle Bone Disease Consortium   +2 more
doaj   +2 more sources

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser, Claire Laurie, Teresa Schmidt, Irene von Luettichau, Peter Bekkering, Sabine Kesting   +5 more
wiley   +1 more source

Change in body temperature, not acute-phase reaction, predict anti-Osteoporosis efficacy after the first administration of Zoledronic acid: a prospective observational cohort study

BMC Musculoskeletal Disorders
Background Acute-phase reactions (APRs) are common among people treated for the first time with zoledronate (ZOL). The current view is that both the APRs caused by ZOL and its efficacy are related to the mevalonic acid pathway.
Yanping Du, Weijia Yu, Haixin Gou, Yiming Lei, Tongkai Zhang, Wenjing Tang, Minmin Chen, Huilin Li, Qun Cheng   +8 more
doaj   +1 more source

The vitamin D status in a Chinese osteogenesis imperfecta population and its correlation with bone metabolic markers and bone density

Frontiers in Nutrition
ObjectiveStudies on the baseline vitamin D levels in osteogenesis imperfecta (OI) patients before medication are scarce. This study assessed the vitamin D status of a population with OI at both the overall level and within different age groups.
Yunyi Jiang, Yazhao Mei, Yuan Tian, Li Shen, Shuqin Xu, Hao Zhang, Zhenlin Zhang   +6 more
doaj   +1 more source

Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]

, 2010
Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
A Timmer, AC Mackey, AG Fraser, Chris J. Taylor, CN Bernstein, CW Thomas Jr, David I. Campbell, DH Present, Dhandapani Ashok, I Tiede, J Glas, LJ Derijks, P Karran, S Al-Safi, Sally A. Connolly, Samantha J. Cordell, Sherman Soman, W Disanti, Y Masunaga   +18 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Peripheral Blood Stem Cell Harvest HPC Count Is an Effective Surrogate Marker for CD34+ Cell Count in Allogeneic Stem Cell Transplant Setting

Translational Oncology, 2020
OBJECTIVE: We assessed the predictive potential of XN-HPC for CD34+ cell count as obtained through Sysmex automated hematology analyzers (XN-1000).
Aisha Jamal, Mohammad Tahir Khan, Sadia Parveen, Qurratulain Rizvi, Tasneem Farzana, Uzma Zaidi, Munira Borhany, Saima Siddiqui, Saqib Hussain Ansari, Tahir Sultan Shamsi   +9 more
doaj   +1 more source

General analysis of mathematical models for bone remodeling

, 2010
Bone remodeling is regulated by pathways controlling the interplay of osteoblasts and osteoclasts. In this work, we apply the method of generalized modelling to systematically analyse a large class of models of bone remodeling.
Gross, Thilo, Siegmund, Stefan, Stiefs, Dirk, Zumsande, Martin   +3 more
core   +1 more source

A statistical method (cross-validation) for bone loss region detection after spaceflight. [PDF]

, 2010
Astronauts experience bone loss after the long spaceflight missions. Identifying specific regions that undergo the greatest losses (e.g. the proximal femur) could reveal information about the processes of bone loss in disuse and disease.
Chu, Philip W, Fang, Jiqian, Kornak, John, Lang, Thomas F, Li, Caixia, Li, Wenjun, Lu, Ying, Zhao, Qian   +7 more
core   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source