Results 201 to 210 of about 110,076 (245)

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Beyond resorption-driven coupling: a multi-layered framework for osteoclast-osteoblast communication and its therapeutic consequences. [PDF]

Front Endocrinol (Lausanne)
Qiu H, Liu S, Jiang Y, Lai Y, Lin Q, Huang A.   +5 more
europepmc   +1 more source

Identification of a new population of Tnn⁺ progenitors to form tendon enthesis fibrocartilage. [PDF]

Bone Res
Zhang T, Zhang L, Yuan Z, Wang L, Hu J, Skutella T, Lu H.   +6 more
europepmc   +1 more source

New knock-in mouse lines <i>Dmp1^em1(CreERT2)</i> and <i>Dmp1^em2(ZsGreen)</i> enable precise osteocyte-specific targeting and visualization. [PDF]

JBMR Plus
Hu YJ, Guo YQ, Wang TH, Yang M, Liu Y, Yang Y.   +5 more
europepmc   +1 more source

Expert consensus on the diagnosis and management of tooth developmental anomalies. [PDF]

Int J Oral Sci
Zhu J, Wan M, Duan X, Fan Z, Sun Y, Wang X, Zheng S, Zheng L, Zhu Q, Chen D, Dai J, Han D, He M, Huang C, Jiang Y, Jia Z, Pan Y, Pan Y, Wang T, Wang W, Xu B, Yin W, Zhang T, Zhang Y, Zhao Z, Bian Z, Song Y.   +26 more
europepmc   +1 more source

Janus kinase inhibitor therapy for the treatment of spondyloenchondrodysplasia with immune dysregulation due to novel <i>ACP5</i> variants: a multicenter study. [PDF]

Front Immunol
Mu H, Liu L, Chen Z, Chen R, Liu X, Wu J, Yang X, Tang X, Zhou L, Jia Y, Patra PK, Wani NA, Gupta S, Zhao X, Banday AZ, An Y.   +15 more
europepmc   +1 more source

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Rheumatological presentation of developmental bone diseases

European Journal of Radiology, 2000
Developmental bone disease may be present, with rheumatological disorders as the major symptoms, even in children. The major lesions encountered are early osteo arthritis, osteo chondromatosis and vertebral involvement with two leading types, pseudo Scheuermann's disease or pseudo ankylosing spondylitis.
G, Kalifa, P A, Cohen, A, Hamidou
openaire   +2 more sources

Dysplasia epiphysealis hemimelica (Trevor disease): a rare developmental disorder of bone mimicking osteochondroma of long bones

Human Pathology, 2007
Dysplasia epiphysealis hemimelica (DEH) is a rare developmental disorder of childhood and is characterized by asymmetric enlargement of the epiphyseal cartilage of the long bones. After 4 to 5 years of age, the lesions histologically resemble osteochondroma.
Rachel, Glick, Lubna, Khaldi, Konrad, Ptaszynski, German C, Steiner   +3 more
openaire   +2 more sources

[Preliminary Study on the Relationship between the Developmental Stage of Multiple Myeloma Disease and the Results of Bone Marrow Whole Exome Sequencing].

Zhongguo shi yan xue ye xue za zhi, 2023
To investigate the genetic results of whole exome sequencing of bone marrow from new onset multiple myeloma (MM) patients to analyze the process of genetic clonal evolution in MM patients.Genomic DNA was extracted from bone marrow samples of 15 MM patients and the whole exomes sequencing was performed using next generation sequencing technology.
Qing-Zhao, Li, Hu, Zhao, Hai-Mei, Chen, Huang, Huang, Juan, Peng, Guo-Yu, Hu, Chan-Juan, Shen, Zhao-Hui, Yuan   +7 more
openaire   +1 more source