Results 231 to 240 of about 441,833 (304)

A different MAPK, ERK5 plays a critical role in cell specification and differentiation. [PDF]

Biochem Biophys Rep
Li J, Hou X, Li X, Ji S.
europepmc   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Exercise-Induced Exerkines Modulate Autophagy: Implications for Interorgan Crosstalk in the Hallmarks of Ageing. [PDF]

Int J Mol Sci
Deng Q, Huang J, Wang C, Liang J.
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Association between the serum uric acid to HDL cholesterol ratio and forearm bone mineral density in middle-aged and older adults. [PDF]

Front Endocrinol (Lausanne)
Song F, Sang Y, Fang X, Tang Z, Zhang L.
europepmc   +1 more source

Obesity Disrupts H3K4me3-Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages. [PDF]

FASEB J
Takahashi K, Drolet J, Liu J, Jackson JR, Babcock M, Thiruppathi M, Fang M, Paul T, Ganesh G, Fukasawa Y, Akasaka Y, Fantuzzi G, Benevolenskaya EV, Koh TJ, Urao N.   +14 more
europepmc   +1 more source

Osteomalacia Following Iron Infusion Therapy in a Patient With Rendu-Osler-Weber Syndrome: F-18-FDG PET/CT Discrimination of a Stress Fracture in the Setting of a Musculoskeletal Tumor Mimic. [PDF]

Clin Case Rep
Vasios IS, Valsamaki PN, Tilkeridis K, Deftereos S, Iliopoulos E.   +4 more
europepmc   +1 more source

Glucocorticoid-induced diabetes mellitus: mechanisms, risk factors, and clinical pathways with insights from autoimmune rheumatic diseases. [PDF]

Rheumatol Int
Soura M, Bakiri A, Fragoulis GE, Vassilakis KD.   +3 more
europepmc   +1 more source

Testosterone plus lifestyle therapy improves skeletal muscle glycolysis in older men with obesity and hypogonadism. [PDF]

Front Endocrinol (Lausanne)
Viola V, Aguilar M, Nava MLD, Celli A, Armamento-Villareal R, Barnouin Y, Napoli N, Putluri N, Qualls C, Villareal DT.   +9 more
europepmc   +1 more source

Gut Microbiota Regulates Brain-Bone Axis to Influence Osteoporosis Pathogenesis and Treatment. [PDF]

Research (Wash D C)
Shi H, Huang L, Zhang JH, Shen C, Zhang N, Lv C, Shao L, Li M, Sun Z, Shi L, Yu G, Chen Y.   +11 more
europepmc   +1 more source