Results 61 to 70 of about 441,833 (304)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Effect of Breastfeeding on the Course of Respiratory Syncytial Virus Infection in Infants: A Single-Center Retrospective Study

Pediatric Reports
Background/Objectives: Respiratory syncytial virus (RSV) is one of the main pathogens causing infections of the respiratory system. In our study, we investigated whether breastfeeding, compared to feeding with formula milk, has an effect on RSV infection
Anna Maćkowska, Jakub Nowicki, Elżbieta Jakubowska-Pietkiewicz   +2 more
doaj   +1 more source

Association between hypomagnesemia and severity of primary hyperparathyroidism: a retrospective study

BMC Endocrine Disorders, 2021
Background The occurrence of hypomagnesemia in patients with primary hyperparathyroidism (PHPT) has been noted previously; however, the association of hypomagnesemia and severity of primary hyperparathyroidism remains unknown.
Ding Na, Guo Tao, Liu Shu-Ying, Wang Qin-Yi, Qu Xiao-Li, Li Yong-Fang, Ou Yang-Na, Sheng Zhi-Feng, Yang Yan-Yi   +8 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Ketogenic diet-induced weight loss is associated with an increase in vitamin d levels in obese adults [PDF]

, 2019
Vitamin D is an important micronutrient involved in several processes. Evidence has shown a strong association between hypovitaminosis D and cardio-metabolic diseases, including obesity.
Gigliotti, S, Maio, R, Perticone, F., Perticone, M, Pinto, A, Pujia, R, Sciacqua, A, Sesti, G, Suraci, E, Zito, R   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency

Scientific Reports, 2022
The protective effect of estrogens against cortical bone loss is mediated via direct actions on mesenchymal cells, but functional evidence for the mediators of these effects has only recently begun to emerge.
Filipa Ponte, Ha-Neui Kim, Aaron Warren, Srividhya Iyer, Li Han, Erin Mannen, Horacio Gomez-Acevedo, Intawat Nookaew, Maria Almeida, Stavros C. Manolagas   +9 more
doaj   +1 more source

How accurate is your sclerostin measurement?:Comparison between three commercially available sclerostin ELISA kits [PDF]

, 2016
Sclerostin, bone formation antagonist is in the spotlight as a potential biomarker for diseases presenting with associated bone disorders such as chronic kidney disease (CDK-MBD). Accurate measurement of sclerostin is therefore important.
Fisher, Emily, Fraser, William D, Greeves, Julie, Jackson, Sarah, Piec, Isabelle, Tang, Jonathan, Washbourne, Christopher   +6 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

FNDC5/irisin-enriched sEVs conjugated with bone-targeting aptamer alleviate osteoporosis: a potential alternative to exercise

Journal of Nanobiotechnology
Exercise maintains bone health and produces protective effects on bone loss. In this study, we investigated the potential protective effects of circulating small extracellular vesicles (sEVs) generated under endurance exercise training (Exe-sEVs) on ...
Min-Zhi Mao, Ming-Hui Zheng, Bei Guo, Ya-Li Ling, Xiao Lin, Fu-Xing-Zi Li, Su-Kang Shan, De-Xing Dai, Lei Qiu, Xue-Yang Cai, Ya Ding, Ying-Ying Gu, Qi-Rong Deng, Zhi-Ang Zhou, Li-Min Lei, Cheng Tao, Rong-Rong Cui, Feng Wu, Fei Zhang, Bo Wu, Le-Le Liao, Chang-Ming Tan, Xiao-Bo Liao, Ling-Qing Yuan, Feng Xu   +24 more
doaj   +1 more source