Results 91 to 100 of about 906,794 (309)
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Circulating miR-126-3p is a mechanistic biomarker for knee osteoarthritis
Nature CommunicationsOsteoarthritis is a major contributor to pain and disability worldwide, yet there are currently no validated soluble biomarkers or disease-modifying treatments.
Thomas G. Wilson +12 more
doaj +1 more source
Vitamin D and Bone Health—Discussion Points Following the Recent Institute of Medicine Recommendations [PDF]
, 2011 Robert P. Heaney
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source
Journal of Orthopaedic Surgery and ResearchBackground Osteochondral lesions of the talus (OLTs) are common ankle injuries that can cause chronic pain and reduced function when conservative treatment fails.
Gokhan Pehlivanoglu +5 more
doaj +1 more source
Comparison of bone health status and physical fitness component between inactive non-bowlers and recreational bowlers [PDF]
, 2021 Ahmad Ariff Zaki Abdillah
openalex
Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
wiley +1 more source