Results 101 to 110 of about 906,794 (309)

Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of osteoarthritis

eLife
Osteoarthritis (OA) is a painful, debilitating disease with no cure or treatments that can predictably stop/reverse its progression. Treatment is particularly difficult since articular cartilage lacks intrinsic repair capacity, despite mesenchymal stem ...
Nedaa Al-Jezani, Asmaa Affan, Catherine Leonard, Nabangshu Das, Luiz Gustavo Almeida, Daniel Young, Anand O Masson, Antoine Dufour, Paul Salo, Pam Railton, James N Powell, Roman J Krawetz   +11 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Changing physical activity behavior among individuals with inflammatory arthritis: an umbrella review of current behaviors, behavioral determinants, and behavior change interventions

BMC Rheumatology
Introduction Physical activity is internationally recommended as an effective component of inflammatory arthritis (IA) care. It contributes to managing IA symptoms, enhancing quality of life, and reducing cardiovascular disease risk.
Manuel Ester, Daniel Gillespie, Saania Zafar, Racheal Githumbi, Kiran Dhiman, Kamala Adhikari, Claire Barber   +6 more
doaj   +1 more source

Warning from a pediatric patient with severe myositis ossificans combined with femoral fracture: a case report

Frontiers in Pediatrics
Myositis ossificans (MO) is a self-limiting benign ossification disorder, characterized by heterotopic ossification within skeletal muscles. Pediatric MO cases are rarer, easy to be misdiagnosed.
Mengyao Wang, Jin Cao, Huanye Zhu
doaj   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Bone health in children with primary hyperoxaluria type 1 following liver and kidney transplantation

Frontiers in Pediatrics
BackgroundPrimary hyperoxaluria type 1 is characterized by hepatic oxalate overproduction, leading to nephrocalcinosis, kidney stones, kidney failure and systemic oxalosis, including oxalate osteopathy.
Rainer Büscher, Lars Pape, Anja K. Büscher   +2 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Smaller and thinner long bones in children and adolescents with cerebral palsy and other neuromotor impairments

Frontiers in Endocrinology
Introduction/BackgroundCompromised bone and muscle health is a significant concern for children and youth with cerebral palsy (CP) and other non-progressive neuromotor impairments.
Erin Hodgson, Erin Hodgson, Erin Hodgson, Erin Hodgson, Elizabeth G. Condliffe, Elizabeth G. Condliffe, Elizabeth G. Condliffe, Elizabeth G. Condliffe, Elizabeth G. Condliffe, Leigh Gabel, Leigh Gabel, Leigh Gabel, Leigh Gabel   +12 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

MON-392 Bone Health in Diabetes - Are We Addressing It? [PDF]

, 2020
Rachana Thapa, Pilar Zambrano, Matthew F. Bouchonville, Christina Lovato, Patricia Kapsner   +4 more
openalex   +1 more source