Results 41 to 50 of about 76,682 (261)

Scientific and engineering staff development for China transport industry

open access: yesАрхитектура, строительство, транспорт, 2023
The paper analyzes the policy and management experience of the China transport industry enterprises in the field of personnel talents development, as well as the results achieved in this direction. The authors evaluate the level of education, employment,
J. Zhang   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Nano-calcium Powder Properties from Six Commercial Fish Bone Waste in Indonesia

open access: yesSqualen, 2022
Low daily calcium intake in Asia, especially in Indonesia, is still a serious problem. The abundant fish bone waste from the fishery fillet industries in Indonesia,  can be employed as an alternative source of calcium to meet daily calcium needs.
Pipin Kusumawati   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Characteristics of industrial and laboratory meat and bone meal ashes and their potential applications [PDF]

open access: yesJournal of Hazardous Materials, 2008
This paper reports the characterization of four meat and bone meal (MBM) ashes obtained from specific incineration (laboratory) and from co-incineration (industrial process). Three out of the four MBM ashes were mainly composed of calcium phosphates (hydroxyapatite and whitlockite).
Coutand, Marie   +4 more
openaire   +5 more sources

Penerapan Developmental State Dalam Sektor Industri Kecil Menengah Di Indonesia: Studi Kasus Kabupaten Bone

open access: yesJournal of Islamic World and Politics, 2018
Kegagalan pertumbuhan ekonomi merupakan masalah utama perekonomian jangka panjang suatu negara. Salah satu bentuk upaya pemerintah untuk mengatasi permasalahan tersebut adalah dengan memperbaiki iklim investasi asing melalui sektor industri kecil ...
Andi Amytia Resty Dwiyanti   +1 more
doaj   +1 more source

Relationship between Bone Stability and Egg Production in Genetically Divergent Chicken Layer Lines

open access: yesAnimals, 2020
Impaired animal welfare due to skeletal disorders is likely one of the greatest issues currently facing the egg production industry. Reduced bone stability in laying hens is frequently attributed to long-term selection for increased egg production.
Simon Jansen   +8 more
doaj   +1 more source

INCIDENCE OF CHICKEN ANEMIA VIRUS IN SHARKIA GOVERNORATE CHICKEN FLOCKS [PDF]

open access: yesAssiut Veterinary Medical Journal, 2014
Chicken anemia virus has a great economic impact on poultry industry all over the world but firstly isolated in Japan, 1979. In this study many suspected chicken flocks with history of weakness, anemia, poor condition and vaccination failure at different
A.M. HEGAZY   +3 more
doaj   +1 more source

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