Results 61 to 70 of about 48,815 (294)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing [PDF]

, 2015
PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalacia ...
Carriero, A, Chang, Y M, Farquharson, C, Houston, D A, Javaheri, B, Kazeruni, B N, Millan, J L, Oldknow, K J, Pitsillides, A A, Salmon, P, Shefelbine, S, Staines, K A   +11 more
core   +4 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Investigating A Dose Response Relationship between High Fat Diet Consumption and the Contractile Performance of Isolated Mouse Soleus, EDL and Diaphragm Muscles [PDF]

, 2019
PurposeRecent evidence has demonstrated an obesity-induced, skeletal muscle-specific reduction in contractile performance. The extent and magnitude of these changes in relation to total dose of high-fat diet consumption remains unclear.
A Abdelmoula, A Matsakas, A Wronska, BH Goodpaster, C Barclay, C Barclay, Cameron Hill, CJ Blimkie, CJ Tanner, D Akhmedov, D Pette, D Tomlinson, DM D’Souza, DS Ward, F Zurlo, FR Paolillo, H Eshima, J Aucouturier, J Ciapaite, J Kemp, J Machann, J Mendez, J Szymura, J Tallis, J Tallis, J Tallis, J Tallis, J Tallis, J Wilde de, Jason Tallis, JD Altringham, JD Bruton, Josh Hurst, KE Shortreed, KE Trajcevski, M Hulens, MA Brotto, MM Thomas, MS Denies, N Miyatake, NA Maffiuletti, NA Maffiuletti, P Capodaglio, P Kopelman, P Rogers, R Singh, RK Josephson, RK Josephson, Rob S. James, RS James, RS James, RS James, S Warmington, SR Anderson, Val M. Cox, Y Rolland, Y Yoshida   +56 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Metabolic and orthopedic management of X-linked vitamin D-resistant hypophosphatemic rickets

Journal of Children's Orthopaedics, 2008
Purpose Therapy of vitamin D-resistant hypophosphatemic rickets (VDXLR) consists of oral phosphate and vitamin D supplements. Bone deformities, pain, and small stature can occur even in children with good compliance, requiring surgical correction and ...
Sandro F. Fucentese, Thomas J. Neuhaus, Leonhard E. Ramseier, G. Ulrich Exner   +3 more
doaj   +1 more source

Fibula-Assisted Segment Transport (FAST) for Defect Reconstruction after Resection of Tibial Adamantinoma: Report of Two Treatments

Case Reports in Orthopedics, 2021
Intramedullary limb lengthening via lengthening nails has been performed for more than three decades to overcome leg length inequalities. Plate-assisted bone segment transport (PABST) has recently been described for the reconstruction of segmental bone ...
A. Rachbauer, A. Laufer, G. Gosheger, G. Toporowski, A. Frommer, E. Jacob, N. Deventer, R. Roedl, B. Vogt   +8 more
doaj   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

A review of the effectiveness of lower limb orthoses used in cerebral palsy [PDF]

, 2009
To produce this review, a systematic literature search was conducted for relevant articles published in the period between the date of the previous ISPO consensus conference report on cerebral palsy (1994) and April 2008.
Bowers, Roy, ISPO (Funder), Ross, Karyn
core  

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source