Results 281 to 290 of about 2,378,510 (365)

A Pilot Study of Bone Marrow Transplantation in a GALT-Null Rat Model of Classic Galactosemia. [PDF]

JIMD Rep
Rasmussen SA, Seemiller MM, Smith I, Wilson M, Daenzer JMI, Wiggins K, Fridovich-Keil JL.   +6 more
europepmc   +1 more source

Steroid Receptor Coactivator‐1 Drives Tumor‐Associated Macrophage Reprogramming by Mediating MMP12 Transcription in Pancreatic Cancer Perineural Invasion

Advanced Science, EarlyView.
Steroid receptor coactivator‐1 (SRC‐1) reprograms tumor‐associated macrophages (TAMs) via signal transducer and activator of transcription 1(STAT1)‐mediated matrix metallopeptidase 12 (MMP12) transcription to drive perineural invasion (PNI) in pancreatic cancer.
Ke Cheng, Liang Liu, Miaomiao Gong, Yuke Ji, Chunmei Bai, Xiangqian Guo, Hui Chen, Jinjin Pan, Ying Zhang, Yuhui Yuan   +9 more
wiley   +1 more source

Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia. [PDF]

Hemasphere
Koedijk JB, Barneh F, Meesters-Ensing JE, van Tuil M, Sonneveld E, Lambo S, Perzolli A, Schweighart EK, Ferrao Blanco MN, van der Meulen M, Deli A, Haasjes E, Bang Christensen K, de Groot-Kruseman HA, Meshinchi S, Hasle H, Belderbos ME, Luesink M, Goemans BF, Nierkens S, Hehir-Kwa J, Zwaan CM, Heidenreich O.   +22 more
europepmc   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis. [PDF]

Nat Aging
Kumar S, Song K, Wang J, Baghel MS, Zeng Y, Shen K, Zheng J, Crane J, Demehri S, Gao P, Jain A, Skolasky RL, Wong P, Cao X, Wan M.   +14 more
europepmc   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Monte Carlo Dose Estimation of Absorbed Dose to the Hematopoietic Stem Cell Layer of the Bone Marrow Assuming Nonuniform Distribution Around the Vascular Endothelium of the Bone Marrow: Simulation and Analysis Study. [PDF]

JMIRx Med
Kobayashi N.
europepmc   +1 more source

Primary Bone Marrow Classic Hodgkin Lymphoma With Haemophagocytic Lymphohistiocytosis. [PDF]

EJHaem
Lee CT.
europepmc   +1 more source