Results 321 to 330 of about 2,949,732 (413)

Inflammation perturbs hematopoiesis by remodeling specific compartments of the bone marrow niche. [PDF]

Blood
Swann JW, Zhang R, Verovskaya EV, Calero-Nieto FJ, Wang X, Proven MA, Hirakawa H, Heubel BP, Shyu PT, Guo XE, Ding L, Gottgens B, Passegue E.   +12 more
europepmc   +1 more source

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

Advanced Science, EarlyView.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang, Pengfei Jiang, Joshua B Stein, Yannan Hou, Chaochen Zhou, Heemin Kang, Ki‐Bum Lee   +6 more
wiley   +1 more source

A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche. [PDF]

Cell Regen
Ma LY, Deng ZH, Bai K, Yu YM, Huang Y, Gao RR, Li YY, Li XL, Yang JX, Shu YH, Ma J, Liu Y, Chen Q.   +12 more
europepmc   +1 more source

Haploidentical bone marrow transplantation for AML in remission after TBF conditioning: a long-term follow-up

Anna Maria Raiola, Carmen Di Grazia, Alida Dominietto, Stefania Bregante, Sabrina Giammarco, Riccardo Varaldo, Federica Sorà, Elisabetta Metafuni, Maria Assunta Limongiello, Antonella Laudisi, Monica Passannante, Eugenio Galli, Massimiliano Gambella, Simona Sica, Andrea Bacigalupo, Emanuele Angelucci, Patrizia Chiusolo   +16 more
openalex   +1 more source

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Sarcoidosis With Pulmonary and Bone Marrow Involvement Following Chemotherapy in a Cancer Patient. [PDF]

Respirol Case Rep
Shirahase K, Nagasaki T, Muraki M, Wakasa T, Hanada S, Iwai M, Tohda Y, Matsumoto H.   +7 more
europepmc   +1 more source

Injectable BMSC‐Based Extracellular Matrix‐Mimicking Microtissue for Myocardial Infarction Repair

Advanced Science, EarlyView.
A novel injectable biomimetic extracellular matrix scaffold (JLSV) is designed for enhanced delivery of bone marrow‐derived mesenchymal stem cells (BMSCs). By utilizing janus basic nanotubes, laminin, stromal‐derived factor‐1 alpha, and vascular endothelial growth factor, this innovative JLSV–BMSC microtissue shows promise in myocardial infarction ...
Lina Yao, Huailong An, Cong Fan, Qingsu Lan, Hongyu Zhong, Yun Zhang, Libo Zhou, Panpan Hao   +7 more
wiley   +1 more source

Bone marrow B lymphopoiesis accelerates early cerebral amyloid pathology. [PDF]

Signal Transduct Target Ther
Zhang J, Fang W, Liu H, Li R, Zhu Z, Wu X, Yao S, Fu Y, Li R, Chen W, Ye Q, Liu Q, Chen X.   +12 more
europepmc   +1 more source

Cancer Immunotherapy via Disruption of Integrin αvβ3 and CD47 Costabilization on Cancer Cell Surface

Advanced Science, EarlyView.
This study identifies a cancer‐specific interaction between CD47 and integrin αvβ3 that facilitates immune evasion. A rationally designed peptide, PSFL‐NK13, disrupts this axis, enhancing macrophage‐mediated phagocytosis and suppressing tumor growth without inducing anemia.
Peng‐Cheng Yu, Chen‐Xi Yue, Wen‐Zhong Dong, Cui‐Yun Hao, Yi‐Fan Qiao, Di Liu, Xin Zhang, Qi Zhan, Jia‐Bao Yao, Dong‐Ping Wang, Peng Cao, Ying‐Zhe Fan, Ye Yu   +12 more
wiley   +1 more source

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source