Results 151 to 160 of about 960,390 (294)

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Contamination with osteoclasts of a bone marrow puncture (human)

open access: yes, 2007
Stain: May-Grnwald-Giemsa (MGG). In the procedure for preparing a bone marrow smear from a sternum puncture osteoclasts are frequently found in the bone marrow smears.
Poels, Lambert G.
core  

Quizartinib Resistance Mutations and Treatment Outcomes in Relapsed or Refractory FLT3‐ITD–Positive AML

open access: yesCancer Science, EarlyView.
ABSTRACT Quizartinib is a FMS‐like tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 internal tandem duplication (FLT3‐ITD)–positive acute myeloid leukemia (AML). We aimed to evaluate quizartinib resistance mechanisms, in addition to efficacy and safety outcomes, in patients with relapsed or refractory FLT3‐ITD–positive AML.
Yuichiro Semba   +21 more
wiley   +1 more source

Survey and detail of bone marrow section (human)

open access: yes, 2007
Stain: modified hematoxylin and eosin (A, B). The bone marrow consists of bone trabecles or crests (1) covered with osteoclasts and osteoblasts. Between the trabecles bone marrow parenchym (2) consisting of progenitor cells, reticular cells and fat cells
Poels, Lambert G.
core  

Neonatal Diamond‐Blackfan anemia with persistent neutropenia caused by an RPS15A variant

open access: yes
Pediatric Investigation, EarlyView.
Hong Zheng   +5 more
wiley   +1 more source

A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells

open access: yesCell Proliferation, EarlyView.
This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang   +10 more
wiley   +1 more source

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