Results 271 to 280 of about 6,967 (325)

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, Volume 15, Issue 19, 22 May 2026.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, Volume 11, Issue 10, 22 May 2026.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

BENEFICIAL EFFECTS OF PERCUTANEOUS CORE DECOMPRESSION WITH BONE MARROW ASPIRATE CONCENTRATE IN THE CLINICAL MANAGEMENT OF AVASCULAR NECROSIS FROM STAGE III TO II: A 28 MONTHS FOLLOW-UP STUDY

Venkatesh Movva1*, Anand Alluru1, Syed Khaleel1, Sunitha Manne Mudhu2, Vijayalakshmi Venkatesan2
openalex   +1 more source

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source

Biological augmentation of anterior cruciate ligament reconstruction with bone marrow aspirate concentrate: a systematic review and meta-analysis of randomised controlled trials. [PDF]

Int Orthop
Park JY, Ng Hing Cheung JA, Todorov D, Park SY, Lim H, Shin E, Yoon A, Ha J.   +7 more
europepmc   +1 more source

Results of minimally invasive core decompression and autologous bone grafting in combination with autologous bone marrow aspirate concentrate in the treatment of patients with aseptic osteonecrosis of the femoral head

Daria A. Naida, Boris V. Tyulkevich, Д А Маланин, Vladimir V. Kondrashenko, Maxim V. Demeshchenko, Н. Н. Чирков   +5 more
openalex   +2 more sources

Quality of life changes in patients suffering from knee osteoarthritis treated with bone marrow aspirate concentrate, platelet-rich plasma and hyaluronic acid injections. [PDF]

Regen Med
Dulic O, Abazovic D, Matijevic S, Rasovic P, Obradovic M, Bjelobrk M, Tosic M, Lalic I, Baljak B, Milinkov M.   +9 more
europepmc   +1 more source

Complication rates of bone marrow aspirate concentrate injections versus other injectable therapies for knee osteoarthritis: A systematic review and meta-analysis. [PDF]

J Orthop
Fucaloro S, Bragg JT, Feldman MW, Krivicich L, Salzler MJ.   +4 more
europepmc   +1 more source

Core Decompression with Bone Marrow Aspirate Concentrate Implantation in Osteonecrosis of the Femoral Head with a Minimum of 2-year Follow-up - A Pilot Study. [PDF]

J Orthop Case Rep
Ferozkhan S, Sivakumar AP, Elumalai SB, Jeyaraman N, Jeyaraman M.   +4 more
europepmc   +1 more source