Results 151 to 160 of about 17,509 (246)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Is core decompression and bone marrow concentrate with demineralized bone matrix and platelet-rich fibrin suitable for treating femoral head osteonecrosis? [PDF]

J Hip Preserv Surg
Cevolani L, Focaccia M, Spazzoli B, Bruschi A, Staals EL, Dozza B, Laranga R, Frisoni T, Sambri A, Montanari A, Bianchi G, Donati DM.   +11 more
europepmc   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Femoral Neck Fracture Non-Union: Treatment with Bone Marrow Concentrate, Demineralized Bone Matrix, and Morselized Allograft and Angular Stable Fixation. Report of 2 Cases. [PDF]

J Orthop Case Rep
Deguée M, Jacquemart N, Fossati A, Wijngaert TVD, Wembou AS, Cornu O.   +5 more
europepmc   +1 more source

STUDY ON TOBRAMYCIN CONCENTRATION IN BONE MARROW

The Japanese Journal of Antibiotics, 1978
KAWASHIMA, MAHITO, TORISU, TAKEHIKO
openaire   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

Assessing the Impact of a Modified Core Decompression Technique on Early-Stage Avascular Necrosis of the Hip Using Bone Marrow Concentrate Adjuvant Therapy: A Retrospective Study. [PDF]

Cureus
Tiwari A, Khillan K, Poddar M, Ranjan V.
europepmc   +1 more source

STUDY ON CEPHALORIDINE CONCENTRATION IN BONE MARROW

The Japanese Journal of Antibiotics, 1977
KAWASHIMA, MAHITO, TORISU, TAKEHIKO
openaire   +1 more source

Mini-Review in Bone Marrow Aspirate Concentrate [PDF]

Biomedical Journal of Scientific & Technical Research, 2021
openaire   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source