Results 241 to 250 of about 548,525 (315)

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Pernicious Anemia Resulting in Intramedullary Hemolysis, Masking Underlying Polycythemia Vera and Mild Alpha-Thalassemia-A Case Report. [PDF]

Case Rep Hematol
Rohner A, Schnegg-Kaufmann AS, Banz Y, Rosenstock P.   +3 more
europepmc   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Chronic Atypical Myelomonocytic Leukemia of Eosinophilic Lineage in a Cat With Feline Leukemia Virus: A First Case Report. [PDF]

Case Rep Vet Med
José MOP, Evelyn MAA, Betsabe BMD, Giovanni SRA, Paulina RC.   +4 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Author Correction: CAR-T cell therapy-related cytokine release syndrome and therapeutic response is modulated by the gut microbiome in hematologic malignancies

Nature Communications
Yongxian Hu, Jingjing Li, Fang Ni, Zhongli Yang, Xiaohua Gui, Zhiwei Bao, Houli Zhao, Guoqing Wei, Yiyun Wang, Mingming Zhang, Ruimin Hong, Linqin Wang, Wenjun Wu, Mohamad Mohty, Arnon Nagler, Alex H. Chang, Marcel R. M. van den Brink, Ming D. Li, He Huang   +18 more
doaj   +1 more source

Fostering the next generation of bone marrow adiposity researchers: the 3rd International Bone Marrow Adiposity Society Summer School 2025 report. [PDF]

Biol Open
Trivanović D, Amorim T, Roque A, Daamouch S, Park YE, Feng T, Bedez M, Podgorski I.   +7 more
europepmc   +1 more source

Pretreated mesenchymal stromal cells and their secretome for kidney disease: mechanisms and applications. [PDF]

Stem Cell Res Ther
Liu Q, Liu G, Sun D, Li S.
europepmc   +1 more source