Positive Effect of Gushukang on Type-H Vessel and Bone Formation
Frontiers in Cell and Developmental Biology, 2020 Gushukang (GSK) is a traditional herbal compound used in Chinese medicine for the treatment of osteoporosis. Numerous studies have been conducted to elucidate the effects of GSK, but the mechanisms underlying these effects remain unclear.
Wantao Li +4 more
doaj +1 more source
The unsolved case of “bone-impairing analgesics”. The endocrine effects of opioids on bone metabolism [PDF]
, 2015 The current literature describes the possible risks for bone fracture in chronic analgesics users. There are three main hypotheses that could explain the increased risk of fracture associated with central analgesics, such as opioids: 1) the increased ...
COLUZZI, FLAMINIA +3 more
core +3 more sources
Muscle and Bone Mass Loss in the Elderly Population: Advances in diagnosis and treatment.
Journal of Biomedicine, 2018 Aging is the result of different functional changes leading to a substantial reduction of all human capabilities. A variety of anatomical and physiological changes occur with advancing age. These changes are more evident in the elderly population.
Carlos J Padilla Colón +6 more
semanticscholar +1 more source
Dual Effects of Lipid Metabolism on Osteoblast Function
Frontiers in Endocrinology, 2020 The skeleton is a dynamic and metabolically active organ with the capacity to influence whole body metabolism. This newly recognized function has propagated interest in the connection between bone health and metabolic dysfunction.
Nathalie S. Alekos +4 more
doaj +1 more source
Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]
, 2017 The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef +9 more
core +2 more sources
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
Nature Communications, 2018 Preservation of bone mass is crucial for healthy ageing and largely depends on adequate responses of matrix-embedded osteocytes. These cells control bone formation and resorption concurrently by secreting the WNT/β-catenin antagonist sclerostin (SOST ...
Steve Stegen +6 more
semanticscholar +1 more source
Nutrients and Dietary Patterns for Osteoporosis
Российский журнал гериатрической медицины, 2023 In order to reduce the risk of falls and fractures in older patients, promoting a healthy lifestyle and ensuring adequate calcium, vitamin D and protein intakes in their diet is of particular importance.
E. V. Ivannikova +2 more
doaj +1 more source
Associations between sedentary time, physical activity and bone health among older people using compositional data analysis [PDF]
, 2018 Introduction : Aging is associated with a progressive decrease in bone mass (BM), and being physical active is one of the main strategies to combat this continuous loss.
Alegre, Luis M. +7 more
core +3 more sources
Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice [PDF]
, 2018 Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass is ...
A Kamalakar +66 more
core +3 more sources
Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age [PDF]
, 2018 Cortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply.
A Goring +10 more
core +5 more sources