Results 41 to 50 of about 6,665,900 (409)

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis

PLoS ONE, 2017
Overexpression or pharmacological activation of SIRT1 has been shown to extend the lifespan of mice and protect against aging-related diseases. Here we show that pharmacological activation of SIRT1 protects in two models of osteoporosis.
K. Zainabadi, Cassie Liu, Alison L M Caldwell, L. Guarente   +3 more
semanticscholar   +1 more source

Association between Sarcopenia and Reduced Bone Mass: Is Osteosarcopenic Obesity a New Phenotype to Consider in Weight Management Settings?

Life, 2023
Sarcopenic obesity (SO) is a frequent phenotype in people with obesity; however, it is unclear whether this links with an impaired bone status. In this study, we aimed to investigate the association between SO and low bone mass, and to assess the ...
Antonino De Lorenzo, Leila Itani, Paola Gualtieri, Massimo Pellegrini, Marwan El Ghoch, Laura Di Renzo   +5 more
doaj   +1 more source

The influence of dairy consumption, sedentary behaviour and physical activity on bone mass in Flemish children : a cross-sectional study [PDF]

, 2015
Background: This cross-sectional study aimed to look for an association in young children between whole body bone mineral content (BMC) and areal bone mineral density (aBMD) and dairy consumption as well as sedentary behaviour (SB) and physical activity (
D'Haese, Sara, De Henauw, Stefaan, De Schepper, Jean, De Smet, Stephanie, Goemaere, Stefan, Michels, Nathalie, Polfliet, Carolien, Roggen, Inge, Sioen, Isabelle, Valtueña, Jara   +9 more
core   +2 more sources

Regulation of bone mass through pineal‐derived melatonin‐MT2 receptor pathway

Journal of Pineal Research, 2017
Tryptophan, an essential amino acid through a series of enzymatic reactions gives rise to various metabolites, viz. serotonin and melatonin, that regulate distinct biological functions.
K. Sharan, Kirsty Lewis, T. Furukawa, V. Yadav   +3 more
semanticscholar   +1 more source

Thy-1 Deficiency Augments Bone Loss in Obesity by Affecting Bone Formation and Resorption

Frontiers in Cell and Developmental Biology, 2018
Healthy bone remodeling results from a balanced bone formation and bone resorption realized by bone-forming osteoblasts and bone-resorbing osteoclasts, respectively.
Ann-Kristin Picke, Ann-Kristin Picke, Graeme M. Campbell, Felix N. Schmidt, Björn Busse, Martina Rauner, Jan C. Simon, Ulf Anderegg, Lorenz C. Hofbauer, Anja Saalbach   +9 more
doaj   +1 more source

Melatonin alleviates senile osteoporosis by regulating autophagy and enhancing fracture healing in aged mice

Bone & Joint Research
Aims: In our previous research, we have found that melatonin (MEL) affects the osteoporotic process. By balancing bone remoulding, autophagy is involved in age-related bone loss.
Denghui Zhang, Tianer Zhu, Jingyao Bai, Chunchun Chen, Junru Wen, Yi Zhou, Xiaoxu Guan   +6 more
doaj   +1 more source

Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response [PDF]

, 2018
Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in bone strength. It is unclear whether this is due to failure of osteocytes to sense strain, osteoblasts to form bone or insufficient mechanical stimulus ...
A Carriero, A Moustafa, AF Pereira, AG Robling, AG Robling, AH Ng, AI Birkhold, AI Birkhold, AM Hanson, AM Weatherholt, B Javaheri, B Javaheri, B Javaheri, B Javaheri, B Kamal, BM Willie, C Liu, C Turner, CA Schneider, CH Turner, CT Rubin, DB Burr, DB Burr, DM Cullen, E Smith, ER Spector, EW Helge, F Bini, G Ducher, H Razi, J Wergedal, JR Mosley, JR Mosley, K Deere, K Deere, KC Lee, KE Poole, KJ Jepsen, LB Meakin, LE Lanyon, LE Lanyon, LE Lanyon, LE Lanyon, M Doube, M Schaffler, M Steiner, MD Brodt, MD Willinghamm, ME Lynch, MM Shimano, N Holguin, N Holguin, N Holguin, N Lara-Castillo, P Lind, P Sztefek, R DeSouza, RH Routh, RL Souza De, SM Millard, SM Ponik, T Jämsä, TC Lee, TK Patel, Y Umemura   +64 more
core   +4 more sources

VDR in Osteoblast‐Lineage Cells Primarily Mediates Vitamin D Treatment‐Induced Increase in Bone Mass by Suppressing Bone Resorption

Journal of Bone and Mineral Research, 2017
Long‐term treatment with active vitamin D [1α,25(OH)2D3] and its derivatives is effective for increasing bone mass in patients with primary and secondary osteoporosis. Derivatives of 1α,25(OH)2D3, including eldecalcitol (ELD), exert their actions through
Yuko Nakamichi, N. Udagawa, Kanji Horibe, T. Mizoguchi, Yoko Yamamoto, Takashi Nakamura, A. Hosoya, S. Kato, T. Suda, N. Takahashi   +9 more
semanticscholar   +1 more source

Mechanical regulation of bone remodeling

Bone Research, 2022
Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by osteoclasts.
Lijun Wang, Xiuling You, Lingli Zhang, Changqing Zhang, Weiguo Zou   +4 more
semanticscholar   +1 more source

Torque change of anterior teeth based on CBCT using a universal table

Эндодонтия Today, 2022
Aim. The thickness of bone tissue in patients with pathological dental inclinations planning orthodontic treatment with fixed equipment.Materials and methods.
I. S. Kopetskiy, N. G. Meskhiya, A. I. Kopetskaya, I. A. Nikolskaya, G. S. Kabisova   +4 more
doaj   +1 more source