Results 231 to 240 of about 83,628 (310)

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Ultrasound‐Mediated Biotransfection of Engineered Bone Marrow Mesenchymal Stem Cells in Treated Bone Defects through Intracellular Cavitation

Advanced Science, EarlyView.
Ultrasound‐mediated biotransfection through intracellular cavitation increases plasmid nuclear translocation and gene transfection efficiency by 284.7% and 131.6% in engineered bone marrow mesenchymal stem cells (BMSCs) compared to traditional ultrasound‐targeted microbubble destruction techniques. The maintained bone morphogenetic protein 2 expression
Zhili Xu, Huijuan Xin, Yu Wang, Renhao Xu, Yanni He, Meijun Zhou, Zhengqiang Yuan, Hongmei Liu   +7 more
wiley   +1 more source

EFFECT OF CALCIUM SNACKING AND PHYSICAL ACTIVITY ON TOTAL BODY BONE MINERAL CONTENT IN 4TH AND 5TH GRADE GIRLS

, 2001
Sudip Bajpeyi, E Dennis, D. Boudreau, D. J. Jacobsen, Kris Sorenson, A. Marcusson, Rick Seip FACSM   +6 more
openalex   +1 more source

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source

Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells

Advanced Science, EarlyView.
Neoeriocitrin enhances osteogenesis in hDPSCs and bone regeneration by targeting Beclin1 to inhibit ubiquitination‐mediated degradation, thereby stabilizing Beclin1 and increasing its protein abundance to activate autophagy. Abstract Human dental pulp stem cells (hDPSCs) are dental‐derived mesenchymal stem cells with robust multipotent differentiation ...
Yu Wu, Haotian Liu, Qunyi Wang, Ting Zhang, Rixin Chen, Qiao Yuan, Xin Tong, Wenrong Yang, Yin Xiao, Fuhua Yan   +9 more
wiley   +1 more source

Additive Manufactured Magnetoelectric Wireless Retainer as the Periodontal Remodeler for Post‐Orthodontic Tissue Reconstruction and Relapse‐Inhibition

Advanced Science, EarlyView.
Orthodontic relapse persists as a 120‐year challenge, as traditional retainers fail to remodel tissue, causing lifelong dependence. This study demonstrates a flexible magnetoelectric retainer (FMOR) enabling wireless periodontal remodeling. FMOR cues shift periodontal ligament cell (PDLC) paracrine signaling, promoting M2 macrophages, osteogenic ...
Haoqi Lei, Jiwei Sun, Peng Chen, Li Hu, Xin Zhou, Shiqiang Gong, Qingming Tang, Xiaoqing Han, Lili Chen, Bin Su   +9 more
wiley   +1 more source

Bone Mineral Content Is Lower in Prepubertal HIV-Infected Children

, 2002
Stephen M. Arpadi, Mary Horlick, John C. Thornton, Patricia A. Cuff, Jack Wang, Donald P. Kotler   +5 more
openalex   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, EarlyView.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

A Herbal‐Piezoelectric Heterojunction Strategy to Potentiate Bacterial Cuproptosis‐Like Death and Remodel the Inflammatory Microenvironment in Infection‐Associated Implant Osteomyelitis

Advanced Science, EarlyView.
A titanium implant coating integrating berberine and copper‐doped strontium titanate leverages ultrasound to compromise bacterial membranes and induce cuproptosis‐like death. This approach resolves S. aureus infections in osteomyelitis models while suppressing inflammation and promoting osseointegration, demonstrating a dual‐functional strategy against
Guannan Zhang, Zehao Li, Ying Lu, Jianbo Song, Xingyu Liang, Peide Han, Xiaohong Yao, Yongqiang Yang, Xiangyu Zhang   +8 more
wiley   +1 more source