Results 171 to 180 of about 263,731 (260)

A multicentric prospective analysis of the management of edentulous jaw fractures in the elderly population: a World Oral Maxillofacial Trauma (WORMAT) project. [PDF]

Oral Maxillofac Surg
Roccia F, Omedè M, Sobrero F, Cremona G, Yilmaz UN, Atabay M, Bourazani M, Skiadas S, Kovačič Ž, Krebs N, Sivrić A, Kordić M, Bottini GB, Goetzinger M, de Oliveira Gorla LF, Pereira-Filho VA, Dediol E, Kos B, Konstantinovic VS, Miković N, Samieirad S, Roig AM, Ferran AP, Laverick S, Mehmet T, Benech R, Dmd MT, Strada C, Jaisani MR, Hassanein AG, Allam MS, Fwacs TA, Volpe F, Copelli C.   +33 more
europepmc   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Early Results of a Novel Method to Treat Bidirectional Elbow Instability: A Pilot Study. [PDF]

J Hand Surg Glob Online
Nwosu C, Jain NS, Saggar R, D'Auria JL, Fowler AL, Kaufmann RA.   +5 more
europepmc   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Clinical outcomes of internal iliosciatic fixation using a conventional reconstruction plate via an anterior approach for acetabular fractures involving the posterior column. [PDF]

Arch Orthop Trauma Surg
Xiong H, Chen H, Cao S, Chen X, Wang F.
europepmc   +1 more source

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

Advanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi, Hao Jia, Jianfei Dong, Linhao Li, Jingqi Cao, Xun Chen, Zhenzhen Jia, Jing Na, Zhijie Yang, Xinyuan Chen, Yubo Fan, Shuhua Yue, Lisha Zheng   +12 more
wiley   +1 more source

Posterolateral Tibial Plateau Fractures-Does Fixation Choice Matter? A Biomechanical Investigation. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Chailertpongsa P, Donnimitsakul S, Laonapakul T, Samrid R, Thienthong K, Twinprai N, Sripadungkul S, Phruetthiphat OA, Apinyankul R.   +8 more
europepmc   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Multicenter Comparison of Modern Plating Options in Fibula, Scapula, and Osteocutaneous Radial Forearm Free Flaps. [PDF]

Otolaryngol Head Neck Surg
Bollig CA, Reddi S, Walia A, Pipkorn PJ, Jackson RS, Puram SV, Rich JT, Paniello RC, Zevallos JP, Stevens MN, Wood CB, Rohde SL, Sykes K, Bur A, Wieser ME, Galloway TLI, Tassone P, Pluchino T, Jorgensen JB, Kakarala K.   +19 more
europepmc   +1 more source