Synthetic cells are engineered herein to respond to an external chemical messenger by the activation of intracellular catalysis. The chemical messenger molecules are catalytically generated by an extracellular enzyme or a mineral surface, whereas the intracellular catalysis emerges via direct enzyme activation or via protein refolding.
Dante G. Andersen+5 more
wiley +1 more source
Bone quality in pycnodysostosis: micropetrosis, locally distorted osteocyte lacuno-canalicular network, and heterogenous mineralization pattern in an adult female patient with multiple fractures. [PDF]
Fratzl-Zelman N+5 more
europepmc +1 more source
Magnetically Guided Mechanoactive Mineralization Scaffolds for Enhanced Bone Regeneration
A 3D‐printed ‘rebar‐concrete’ inspired scaffold (PGS‐P@MGel) synergizes spontaneous biomineralization with magneto‐mechanical stimulation through PDA@Fe3O4‐embedded hydrogel. This dual biointerface activates Piezo1/β‐catenin/YAP mechanotransduction axis, enhancing BMSCs osteogenesis and angiogenesis simultaneously.
Xuran Guo+10 more
wiley +1 more source
Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running. [PDF]
Birks S+9 more
europepmc +1 more source
Conformally Perforated Shellular Metamaterials with Tunable Thermomechanical and Acoustic Properties
This study introduces Conformally Perforated Shellular Metamaterials (CPSMs), which overcome TPMS design limitations by mapping 2D cellular layouts onto 3D surfaces. CPSMs exhibit enhanced elastic stiffness, thermal conductivity, and acoustic performance compared to intact P‐type shellulars, demonstrating their potential as multifunctional ...
Benyamin Shahryari+8 more
wiley +1 more source
Zinc Glycine supplementation improves bone quality in meat geese by modulating gut microbiota, SCFA's, and gut barrier function through Wnt10b/NF-κB axis. [PDF]
Zulfiqar Z+7 more
europepmc +1 more source
The study presents biodegradable and recyclable mixed‐matrix membranes (MMMs), hydrogels, and cryogels using luminescent nanoscale metal‐organic frameworks (nMOFs) and biopolymers. These bio‐nMOF‐MMMs combine europium‐based nMOFs as probes for the status of the materials with the biopolymers agar and gelatine and present alternatives to conventional ...
Moritz Maxeiner+4 more
wiley +1 more source
The predictive value of endplate morphology and pedicle screw bone quality score on screw loosening after single-level lumbar spinal fusion surgery. [PDF]
Zhan J+6 more
europepmc +1 more source
CD105‐LNPs and PS‐LNPs can deliver α‐lipoic acid to bone marrow mesenchymal stem cells and bone marrow‐derived macrophages, reversing high glucose‐induced oxidative stress while enhancing osteogenesis and M2 polarization. Integrating both nanoparticles into glucose‐responsive hyaluronic acid hydrogel forms DLNPs@HA hydrogel, which accelerates diabetic ...
Yanzhi Zhao+11 more
wiley +1 more source