Results 221 to 230 of about 77,306 (289)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Antenatal education for labour and postpartum pain: A scoping review of content, delivery approaches, evidence gaps, and lived experiences. [PDF]

PLoS One
Sloyan E, Leddy E, Clark C, Dufour S, Harper R, Dunford A, Elma Ö.   +6 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Feasibility and Acceptability of a Multilayered COVID-19 Mitigation Intervention for Adults With Cancer.

JAMA Netw Open
Hoerger M, Pyke N, Zimmerman DE, Srikrishna D, Garg N, Mikles B, Eastman J, Hall CJ, Peter RG, Gerhart JI.   +9 more
europepmc   +1 more source

Culturally appropriate physical activity promotion strategy package among older Chinese adults in the UK: a feasibility randomised control trial protocol. [PDF]

Pilot Feasibility Stud
Yang Y, Lazo Green K, Zhang N, McGarrigle L, Todd C.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

PilOT-Measure: a mobile 3D depth sensing application to support accurate and efficient clinician-led home-based falls risk assessments. [PDF]

BMC Med Inform Decis Mak
Ibrahim Z, Money AG, Atwal A, Spiliotopoulou G.   +3 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

EMTReK Model for Advance Care Planning in Long-Term Care: Qualitative Findings from mySupport Study. [PDF]

Geriatrics (Basel)
Hartigan I, Buckley C, Cornally N, Brazil K, Doherty J, Walshe C, Harding AJE, Preston N, Bavelaar L, van der Steen JT, Di Giulio P, Gonella S, Kaasalainen S, Sussman T, Tétrault B, Loučka M, Vlčková K, Gonzales RA, On Behalf Of The mySupport Study Group.   +18 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source