Results 31 to 40 of about 34,189 (218)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
AISTHESIS EN EL REALISMO CRÍTICO DE LA CIUDAD Y LOS PERROS DE MARIO VARGAS LLOSA
Revista Chilena de Literatura, 2011 Lo nuevo de la "nueva novela hispanoamericana", que La ciudad y los perros (1962) de Mario Vargas Llosa representa, se halla en el re-trabajo de las categorías suministradas por la tradición realista bajo premisas que buscan despertar en el lector ...
José Morales Saravia
doaj
INDEX Revista de Arte Contemporáneo, 2017 Este artículo analiza la exposición Latin American Artists of the Twentieth Century (Museum of Modern Art - MOMA, Nueva York, 1992-1993) situada en el contexto histórico cultural más amplio del cual forma parte: los cambios en el sistema global del arte ...
María Laura Ise
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Methodology for the Regulation of Boom Sprayers Operating in Circular Trajectories
Sensors, 2011 A methodology for the regulation of boom sprayers working in circular trajectories has been developed. In this type of trajectory, the areas of the plots of land treated by the outer nozzles of the boom are treated at reduced rates, and those treated by ...
Alfredo Serreta +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Carlos Fuentes: la obra que palpita
Kipus: Revista Andina de Letras y Estudios Culturales, 2012 En este trabajo se presenta una reflexión acerca de las aportaciones de Carlos Fuentes a la cultura mexicana y latinoamericana; se toma en cuenta la imagen polémica del escritor en su faceta de diplomático e intelectual con el fin de subrayar la ...
Celene García Ávila
doaj
Journal of Mechanical EngineeringIn this study, a model of a quick-coupler device is investigated and presented within simulation modeling software. A method is presented that enables the design and construction of a simulation model of a quick-release device as an alternative to ...
Danyarova Assiya +3 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source