Results 111 to 120 of about 21,439 (303)
Application of sonic-boom minimization concepts in supersonic transport design
, 1973 The applicability of sonic boom minimization concepts in the design of large supersonic transport airplanes capable of a 2500-nautical-mile range at a cruise Mach number of 2.7 is considered.
Mack, R. J. +2 more
core
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Feasibility study of a very big crawler crane using composite materials
Composites Part C: Open AccessThe main goal of this research is to design a very big crawler crane adopting composite material to lightweight the machine itself and compare its performance with the one made of classical structural steel.
Luigi Solazzi
doaj +1 more source
Supersonic airplane design optimization method for aerodynamic performance and low sonic boom
, 1992 This paper presents a new methodology for the optimization of supersonic airplane designs to meet the dual design objectives of low sonic boom and high aerodynamic performance.
Edwards, Thomas A., Cheung, Samson H.
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G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Jixie qiangdu, 2015 The accidents of truck crane happen frequently during working because of the structure failure of hoist boom,which result in severe economic loss and casualties.
QU FuZheng, SUN Qi, XIE ZhengYi
doaj
The Boom Design of the De-Orbit Sail Satellite
, 2014 DE-ORBIT SAIL is a cubesat based drag sail for the de-orbiting of satellites in a low earth orbit. It is scheduled for launch in late 2014 and will deploy a 25m² sail supported by deployable carbon fiber booms designed and manufactured by DLR.
Zander, Martin +4 more
core
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility
Advanced Science, EarlyView.PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao +7 more
wiley +1 more source
Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean
Advanced Science, EarlyView.This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma +11 more
wiley +1 more source