Results 131 to 140 of about 372,468 (300)

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

A new multilevel buck-boost inverter structure using six active switches

Journal of Mechatronics, Electrical Power, and Vehicular Technology
Generally, multilevel inverters function as voltage step-down or step-up converters. This paper discussed a new type of multilevel inverter, specifically five-level and seven-level designs that use six active switches, which can increase or decrease the ...
Leonardus Heru Pratomo, Florentinus Budi Setiawan, Sushil Paudel   +2 more
doaj   +1 more source

Giant Magneto‐Optical Effects in Two‐Dimensional Flat‐Band Antiferromagnets

Advanced Science, EarlyView.
RuOCl2${\rm RuOCl}{_2}$, a two‐dimensional antiferromagnet, hosts energy bands with pronounced directional flatness. This study demonstrates that the flat‐band‐induced optical transitions yield strongly anisotropic absorption and a record‐large magneto‐optical Schafer–Hubert effect, alongside exceptional linear dichroism exceeding 50%.
Ping Yang, Wanxiang Feng, Siyuan Liu, Shan Guan, Liwei Wen, Wei Jiang, Gui‐Bin Liu, Yugui Yao   +7 more
wiley   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Doubly grounded buck‐boost PV grid‐connected inverter without shoot‐through problem

Electronics Letters
Transformerless grid‐connected inverters (GCIs) are universally utilized in the PV system. However, they have the shoot‐through issue and common mode leakage current (CMLC).
Zhilei Yao, Ximing Zhang, Changlei Shan
doaj   +1 more source

Flexible Common-Mode Voltage Modulation Strategy for Differential Boost Inverters

Energies
Photovoltaic power generation and energy storage technology are current hotspots in the clean energy industry. As a core piece of equipment, an inverter is subjected to higher demands for its voltage regulation range and output performance.
Zhaozhe Deng, Hao Qin, Wenbo Zhu, Qi Qiu, Yan Deng, Xiangning He   +5 more
doaj   +1 more source

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle

Advanced Science, EarlyView.
This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu   +9 more
wiley   +1 more source

Dual input switched-capacitor-based singlephase hybrid boost multilevel inverter topology with reduced number of components

, 2020
Dual input switched-capacitor-based singlephase hybrid boost multilevel inverter topology with reduced number of ...
M Rawa (13400076), S Mekhilef (9885539), MD Siddique (14454507), NM Shah (14454510), Ben Horan (13060767), A Stojcevski (9877742), M Seyedmahmoudian (9885542), H Bassi (13513855)   +7 more
core  

DC-DC Boost Converter with Constant Output Voltage for Grid Connected Photovoltaic Application System [PDF]

, 2010
The main purpose of this paper is to introduce an approach to design a DC-DC boost converter with constant output voltage for grid connected photovoltaic application system.
Chan, Pui Weng
core