Results 291 to 300 of about 197,741 (365)

IL-25 Enhances Eosinophil-Associated Inflammation in Angiostrongylus cantonensis-Infected Mice. [PDF]

Parasite Immunol
Chuang CC, Wu WB, Wang JJ, Ma MC, Du WY.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A phase 1 study of a second experience with Group Retreat Psilocybin Therapy for partial responders after a first experience. [PDF]

Front Public Health
Back AL, McGregor BA, Thorn LL, Harvey K, Blom D, Callan G, Guy J, Kumar S, Hershberg R, Layer M, Levin J, Myers S, Perez J, Salmonson K, Thompson P, Whinney J.   +15 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Long-term immune response to mRNA anti-SARS-CoV-2 vaccination in patients with cancer. [PDF]

Front Immunol
Lobo-Martins S, Martins-Branco D, Padonou F, Dahma H, van den Wijngaert S, Jaouart M, Dauccia C, Molinelli C, Agostinetto E, Loizidou A, Taylor D, Boisson A, Garaud S, Spilleboudt C, Vicente Cardona J, Ramge P, Balas BI, Bajji M, George F, Delsaute T, Paesmans M, Ameye L, Piccart M, de Azambuja E, Willard-Gallo K.   +24 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Characteristics of COVID-19 vaccine hesitancy in university students: Methodological insights from a syndemic perspective. [PDF]

Hum Vaccin Immunother
Yu T, Yuan J, Wang L, Li M.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Surveillance and vaccine effectiveness of pertussis, the Netherlands, 2012 to 2024, with an unprecedented surge in 2023 and 2024. [PDF]

Euro Surveill
van Roon A, van Meijeren D, de Gier B, Te Wierik M, de Melker H.   +4 more
europepmc   +1 more source

COVID-19 boosters restore virus-specific immune responses in kidney transplant recipients unresponsive to primary vaccination. [PDF]

Npj Viruses
den Hartog Y, van Sleen Y, Gommers L, Zaeck LM, Geers D, Messchendorp AL, Sanders JF, Baan CC, van Baarle D, de Vries RD, RECOVAC Consortium.   +10 more
europepmc   +1 more source