Results 181 to 190 of about 1,217,759 (290)

Safety and Cross-Neutralizing Immunity Against SARS-CoV-2 Omicron Sub-Variant After a Booster Dose with SOBERANA^® Plus in Children and Adolescents. [PDF]

Vaccines (Basel)
García-Rivera D, Rodríguez-González M, Paredes-Moreno B, Puga-Gomez R, Ricardo-Delgado Y, Silva CV, Fernández-Castillo S, Pérez-Nicado R, Rodríguez-Noda L, Santana-Mederos D, Climent-Ruiz Y, Noa-Romero E, Cruz-Sui O, Sánchez-Ramírez B, Hernández-García T, Palenzuela-Diaz A, Valdés-Balbín Y, Vérez-Bencomo VG.   +17 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Economic evaluation of the second booster dose of diphtheria-tetanus-acellular pertussis vaccine for children aged 6 years in Zhejiang Province: A cost-utility analysis. [PDF]

Hum Vaccin Immunother
Su Y, Zhou Y, Luo F, Zheng S, He H, Zhu Y, Tang X.   +6 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Phase 2/3 study evaluating safety, immunogenicity, and noninferiority of single booster dose of AVX/COVID-12 vaccine. [PDF]

Sci Adv
López-Macías C, Torres M, Armenta-Copca B, Wacher NH, Galindo-Fraga A, Castro-Castrezana L, Colli-Domínguez AA, Cervantes-Trujano E, Rucker-Joerg IE, Lozano-Patiño F, Rivera-Alcocer JJ, Simón-Campos A, Sánchez-Campos EA, Aguirre-Rivero R, Muñiz-Carvajal AJ, Del Carpio-Orantes L, Márquez-Díaz F, Rivera-Hernández T, Torres-Flores A, Ramírez-Martínez L, la Rosa GP, Rojas-Martínez O, Suárez-Martínez A, Peralta-Sánchez G, Carranza C, Juárez E, Zamudio-Meza H, Carreto-Binaghi LE, Viettri M, Romero-Rodríguez D, Palencia A, Sarfati-Mizrahi D, Sun W, Chagoya-Cortés HE, Castro-Peralta F, Palese P, Krammer F, García-Sastre A, Lozano-Dubernard B.   +38 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Immunogenicity of second booster-dose COVID-19 mRNA vaccine among older adults in Taiwan. [PDF]

Biomed J
Lee HY, Chuang CH, Huang CG, Chuang TC, Kung YA, Chiu CH.   +5 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Immunogenicity and reactogenicity of a booster dose of a typhoid conjugate vaccine (TCV) in Malawian pre-school children. [PDF]

EClinicalMedicine
Nampota-Nkomba N, Nyirenda OM, Datta S, Mapemba V, Patel PD, Misiri T, Mwakiseghile F, Ndaferankhande JM, Lipenga B, Oshinsky J, Pasetti MF, Jamka LP, Gordon MA, Laurens MB, Neuzil KM, TyVAC team.   +15 more
europepmc   +1 more source