Results 271 to 280 of about 719,228 (391)

A Joint Pharmacometric Model of Iohexol and Creatinine Administered through a Meat Meal to Assess GFR and Renal OCT2/MATE Activity

Clinical Pharmacology &Therapeutics, EarlyView.
Accurately assessing glomerular filtration rate (GFR) from plasma creatinine concentrations is challenging in patients with unstable renal function. This study aimed to refine the understanding of creatinine kinetics for more reliable assessments of GFR and net creatinine tubular secretion (nCTS) via OCT2/MATE in humans.
Zhendong Chen, Qian Dong, Charalambos Dokos, Jana Boland, Uwe Fuhr, Max Taubert   +5 more
wiley   +1 more source

Temporal changes in the bacterial microbiome of the salivary gland and midgut tissues of Rhipicephalus sanguineus (s.l.) ticks in South Africa. [PDF]

Sci Rep
Ackermann RE, Gall CA, Brayton KA, Collins NE, van Wyk I, Wentzel J, Kolo AO, Oosthuizen MC.   +7 more
europepmc   +1 more source

Balanced Importance Resampling for the Bootstrap [PDF]

, 1993
James G. Booth, Peter Hall, Andrew T. A. Wood   +2 more
openalex   +1 more source

Modeling and Simulation to Inform Apixaban Dosing in Pediatrics With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Treated With Asparaginase

Clinical Pharmacology &Therapeutics, EarlyView.
Apixaban could be a potential treatment option for the prevention of venous thromboembolism (VTE) in children with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL). This analysis describes an updated two‐compartment population pharmacokinetic (PPK) model that characterizes the PK variability of apixaban in pediatric patients with ALL ...
Praneeth Jarugula, Toni Ajavon‐Hartmann, Obinna Obianom, Elizabeth Ludwig, Christina Crevar, David Marchisin, Zhaoqing Wang, Weidong Chen, Bing He, Lesley G. Mitchell, Vilmarie Rodriguez, Glen Lew, Vidya Perera, Bindu Murthy, Samira Merali   +14 more
wiley   +1 more source

Quantification of the effect of hemodynamic occlusion in two-photon imaging of mouse cortex. [PDF]

Elife
Yogesh B, Heindorf M, Jordan R, Keller GB.   +3 more
europepmc   +1 more source

Almost Sure Bootstrap of the Mean Under Random Normalization [PDF]

, 1993
Steven J. Sepanski
openalex   +1 more source

Alemtuzumab Exposure and T Lymphocyte Depletion: A Population Pharmacokinetic‐Pharmacodynamic Model of Alemtuzumab Induction Therapy for Kidney Transplantation

Clinical Pharmacology &Therapeutics, EarlyView.
Alemtuzumab is a T cell‐depleting monoclonal antibody that is used for the prevention of kidney transplant rejection. The duration of lymphodepletion after the current standard induction therapy dose is likely longer than necessary, resulting in prolonged T cell lymphopenia with the associated risk of infections. Here, the interplay between alemtuzumab
Lukas K. van Vugt, Tom C. Zwart, Suzanne Bezstarosti, Sebastiaan Heidt, Marlies E. J. Reinders, Dennis A. Hesselink, Aiko P. J. de Vries, Brenda C. M. de Winter, Dirk Jan A. R. Moes   +8 more
wiley   +1 more source

High throughput sequencing sheds light on the viral diversity in Aedes aegypti mosquitoes from Binh Thuan Province, Vietnam. [PDF]

PLoS One
Popova M, Gladkikh A, Sharova A, Arbuzova T, Sbarzaglia V, Klyuchnikova E, Tsyganova N, Forghani M, Gritseva A, Ramsay E, Dong NT, Phu BT, Hung DT, Dedkov V.   +13 more
europepmc   +1 more source

Relationship between Dose, Factor IX Activity Levels and Bleeding Probability for rIX‐FP Prophylaxis in Hemophilia B: A Repeated Time‐to‐Event Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
In hemophilia B, pharmacokinetic (PK)‐guided dosing of extended half‐life factor IX (EHL‐FIX) concentrates can secure targeted FIX exposure. Target FIX activity levels in plasma should be individually set primarily taking bleeding tendency into account, alongside the presence of target joints, physical activity, and preferred dosing schedules. In other
Sjoerd F. Koopman, Marjon H. Cnossen, Ron A.A. Mathot, on behalf of the OPTI‐CLOT study group and SYMPHONY consortium, S. H. Reitsma   +4 more
wiley   +1 more source

Statistical inference of the generalized process capability index for the discrete lindley distribution. [PDF]

Sci Rep
Hamdi WA, Akdoğan Y, Erbayram T, Alqawba M, Afify AZ.   +4 more
europepmc   +1 more source