Results 141 to 150 of about 1,355 (166)

Machine Learning‐Driven Predictive Modeling and Multi‐Objective Exploration of Oxaliplatin‐Loaded Nanocarriers for Enhanced Loading and Encapsulation Efficiency

open access: yesMaterials Genome Engineering Advances, EarlyView.
Integrating ML and multi‐objective optimization enabled efficient, accurate design of nanocarriers with optimized loading and encapsulation efficiencies. ABSTRACT Oxaliplatin (OXA), a critical third‐generation platinum chemotherapeutic, is significantly limited by suboptimal loading capacity and encapsulation efficiency in nanoparticle‐based delivery ...
Abbas Rahdar   +3 more
wiley   +1 more source

Uncertainty Quantification for Cardiac Diffusion Tensor Imaging Without Additional Datasets

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Cardiac diffusion tensor imaging (cDTI) is subject to physiological noise, thermal noise, and signal corruption, which cause errors in diffusion measures. While a larger dataset can be decimated to investigate the general precision of measures from fitting smaller datasets, uncertainty quantification (UQ) methods for fitting entire ...
Sam Coveney   +7 more
wiley   +1 more source

Understanding the effects of patch‐burn grazing management on aboveground grassland invertebrate biodiversity

open access: yesOikos, EarlyView.
Landscape heterogeneity is widely recognized as a driver of biodiversity, yet its consequences for above‐ground, foliage‐dwelling insect communities under active grassland management remain underexplored. Patch‐burn grazing (PBG), which rotates fire across patches within a grazed landscape, is designed to promote spatial and temporal heterogeneity by ...
Zachary L. T. Bunch   +5 more
wiley   +1 more source

Dress for success: climate pressures predict fur insulation and body size in natural and reintroduced populations of a threatened marsupial

open access: yesOikos, EarlyView.
Phenotypic variation in functional traits underpins responses to environmental gradients, influencing thermoregulation, energy balance, and long‐term persistence under climate extremes. Climate change is altering these gradients globally, yet in species that have already disappeared from much of their range, adaptive phenotypes may have also been lost,
Jack Bilby   +4 more
wiley   +1 more source

Hypovitaminosis D in acute inpatient cancer rehabilitation: Prevalence, predictors, and practical implications

open access: yesPM&R, EarlyView.
Abstract Background Hypovitaminosis D is associated with adverse health outcomes, including increased mortality in patients with cancer. Although vitamin D insufficiency (23%–72%) and deficiency (20%–71%) are common among patients admitted to inpatient rehabilitation, their prevalence and predictors in cancer‐specific inpatient rehabilitation ...
Jegy M. Tennison   +7 more
wiley   +1 more source

Head‐to‐Head Comparison of Four Ultrasound Elastography Techniques in Detecting Advanced Fibrosis

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
Elastography is an important noninvasive method for diagnosing advanced fibrosis (AF); however, evidence remains insufficient, particularly regarding acoustic radiation force impulse (ARFI) techniques. This prospective mulitcenter study concludes that vibration controlled transient elastography (VCTE) demonstrates superior diagnostic performance to ...
Jiahao Han   +8 more
wiley   +1 more source

Informing the potential of mature temperate forests as natural climate solutions: Changed fine root biomass and morphology under elevated CO2

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
The land carbon sink absorbs approximately 25% of anthropogenic CO2 emissions, with forests accounting for most. Managing forests as Natural Climate Solutions is therefore a societal imperative, requiring models of where and how long carbon resides within these ecosystems. We investigated the effects of elevated CO2 on fine roots, the primary source of
Grace Handy   +13 more
wiley   +1 more source

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito   +6 more
wiley   +1 more source

Evaluating astigmatid mites as supplemental food for Macrolophus pygmaeus: contrasting responses between commercial and wild populations

open access: yesPest Management Science, EarlyView.
Astigmatid mites provide low‐cost supplemental food for Macrolophus pygmaeus, supporting survival and development, with population‐specific responses and Acarus siro and Carpoglyphus lactis as the most promising alternatives. Abstract BACKGROUND Early establishment of Macrolophus pygmaeus in crops depends on the availability of supplemental food ...
María del Carmen Reche   +5 more
wiley   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai   +6 more
wiley   +1 more source

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