Results 31 to 40 of about 204 (161)

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, EarlyView.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core

Chemistry – A European Journal, EarlyView.
RNA‐cleaving agents on a cubic octameric silsesquioxane core were synthesized and characterized. Several catalytic systems of these structures were screened using hexaribonucleotide models. The best systems were then further used to study their catalytic efficiency in cleaving a HER2 mRNA model sequence. The induced cleavage sites were also determined.
Hanni Haapsaari, Iris Tuomi, Pasi Virta
wiley   +1 more source

Should multinationals care about development? Rethinking global strategy in an unequal world

Global Strategy Journal, EarlyView.
Abstract Research Summary While multinational corporations (MNCs) can profoundly shape global development trajectories, global strategy research has largely treated development as peripheral to core strategic concerns. This Perspective paper examines the contested relationship between global strategy and development, arguing that MNCs are neither ...
Marcus M. Larsen, Rajneesh Narula, Thomas DeBerge   +2 more
wiley   +1 more source

Biomaterials for resolution of peri‐implantitis: Consensus report of Workgroup 2 of the IADR Implantology Research Group Best Evidence Consensus Symposium on Peri‐Implant Disease and Its Treatment

Journal of Periodontology, EarlyView.
Abstract Background Peri‐implantitis is a destructive disease affecting the tissues surrounding dental implants. Biomaterials may be applied during surgical treatment to reconstruct bony defects and support soft tissue healing. However, current evidence is unclear if these treatments increase the likelihood of peri‐implantitis resolution.
Sukirth M. Ganesan, David R. Fraser, Mustafa Tattan, Jessica M. Latimer, IADR IRG Peri‐Implantitis Best Evidence Consensus Working Group 2, Mario Aimetti, Hatice Hasturk, Purnima S. Kumar, Fernando Suarez Lopez Del Amo, Andreas Stavropoulos, Daniel S. Thoma, Spyridon Vassilopoulos, Hom‐Lay Wang, Georgios Kotsakis   +13 more
wiley   +1 more source

Effectiveness of nonsurgical re‐instrumentation of residual pockets as step 3 of periodontal therapy: A field study

Journal of Periodontology, EarlyView.
Abstract Background The study aims to analyze the effectiveness of nonsurgical re‐instrumentation of residual pockets as step 3 of periodontal therapy and the stability of treatment outcomes at 18 months. Methods The study sample consisted of 489 patients diagnosed and treated nonsurgically for periodontitis.
Anna Liss, Kajsa H. Abrahamsson, Maria Welander, Cristiano Tomasi   +3 more
wiley   +1 more source

Predicting peri‐implantitis incidence and implant failure via risk‐assessment and prognostication tools: A validation study

Journal of Periodontology, EarlyView.
Abstract Background Identifying individuals at high risk for developing peri‐implantitis (PI) and then determining the prognosis for implants with PI is crucial for treatment planning. Methods This study longitudinally followed implants from implant placement retrospectively.
Muhammad H. A. Saleh, Era Kakar, Giuseppe Troiano, Hamzeh Almashni, Jonathan Misch, Fariba Esperouz, Shahad Alhazmi, Hom‐Lay Wang, Zoltán Baráth, Istvan A. Urban   +9 more
wiley   +1 more source

Proyecto de puente en el paso Bopal sobre el Río Grande de Matagalpa (Nicaragua)

, 2012
UBU.
Ratón Alomar, Sergio Agustín, Sacristán Terradillos, Miriam, Cid González, Alfonso, Estrada Merino, Raquel   +3 more
openaire   +1 more source

Mapping the subgingival HerBiome and HisBiome over the human healthspan

Journal of Periodontology, EarlyView.
Abstract Background Understanding the intricate relationship between sex, age, and the oral microbiome is crucial for deciphering the onset and progression of numerous age‐related oral and systemic diseases. Methods Subgingival plaque was collected from 781 periodontally and systemically healthy females and 160 males spanning 0 to 80 years.
Rahul Nikam, Kazune Pax, Michelle Lee‐Scott Beverly, Purnima S. Kumar   +3 more
wiley   +1 more source

A multicenter, controlled, randomized trial of home‐applied dual‐light photodynamic therapy in stage I to III periodontitis (LumoNorth2022 study)

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis is a widespread, chronic infection‐triggered inflammatory condition in which professional supportive periodontal care (SPC) and daily oral hygiene form the backbone to reduce the disease activity. Light‐based treatments have shown promising antibacterial effects, but their potential for routine home use has not been ...
Paula Tegelberg, Meeri Ojala, Merja Ylipalosaari, Jori Lindroth, Anna Maria Heikkinen, Hanna Lähteenmäki, Saila Pakarinen, Ismo T. Räisänen, Timo Sorsa, Tommi Pätilä   +9 more
wiley   +1 more source

Unsupervised phenotyping of the periodontal architecture through high‐dimensional clustering of electronic health records: A multicenter study

Journal of Periodontology, EarlyView.
Abstract Background To identify novel periodontal phenotypes using unsupervised machine learning on a large‐scale, multicenter cohort, specifically characterizing disease patterns based on the “periodontal architecture” of localized structural failures (tooth mobility and molar furcation defects) rather than global severity averages alone. Methods This
Georgios S. Chatzopoulos, Larry F. Wolff
wiley   +1 more source