Results 231 to 240 of about 2,284,562 (345)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Ultrasound imaging of the spinal accessory nerve in the neck. [PDF]

Ultrasound
Fenech M, Appavoo Juhasz K.
europepmc   +1 more source

Illegal immigration and enforcement along the southwest border [PDF]

Pia M. Orrenius
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Anatomical Study of the Angular Branch of the Thoracodorsal Artery and the Lateral Border of the Scapula With Application to Reconstructive Surgery. [PDF]

Cureus
Lesser ER, Samrid R, Pujol J, Bishop J, Rosbrugh J, Bubb KC, Raeburn KT, Barton BM, Iwanaga J, Tubbs RS.   +9 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Drivers and dynamic mechanisms of sports tourism integration in cross-border regions: Evidence from the Guangdong-Hong Kong-Macao Greater Bay Area. [PDF]

PLoS One
Yuan J, Chen C, Luo Z, Liu Y.
europepmc   +1 more source

Invisible borders [PDF]

Nature, 2014
openaire   +2 more sources

Orphans of letters in the Amazonian context: memories of a teaching practice in EJA in the Triple Border Brazil-Peru-Colombia

, 2018
Silva, Maria Cristina da; Universidade Estadual do Ceará, UECE, Fortaleza, CE
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source