Results 171 to 180 of about 296,467 (311)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Emerging East-West corporate networks in Central European border regions: Some theoretical arguments and stylized facts [PDF]

Economic re-integration after a long period of separation among countries with different levels of development is expected to start in border regions. Enterprises along the borderline can gain a rent due to low transport and transaction costs.
Gerling, Katja, Schmidt, Klaus-Dieter
core  

Temporary increase of official controls at border control posts in the European Union: theoretical assessment of the measures laid down in Commission Implementing Regulation EU/2019/1793. [PDF]

Ital J Food Saf
Ciccarelli C, Semeraro AM, Di Trani V, Leinoudi M, Martelli V, Ciccarelli E.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

National Southwest Border Counternarcotics Strategy: Unclassified Summary

, 2007
In the summer of 2006, DHS and DOJ brought both policy makers and frontline officials together to build a Strategy implementation plan from the ground up.
United States Office of National Drug Control Policy
core  

ANALYSIS OF THE RESULTS OF BORDER CONTROL AT THE CHECKPOINTS ON THE STATE BORDER OF UKRAINE WITH THE REPUBLIC OF MOLDOVAIN THE CONTEXT OF THE IMPLEMENTATION OF EUROPEAN INTEGRATION PROCESSES

У статті узагальнено відповідно до вимог нормативно-правових документів заходи євроінтеграційних процесів стосовно прикордонного контролю в пунктах пропуску через державний кордон України та Республіки Молдова, до яких належать: здійснення своєчасного ...
ФАРІОН, Олег, Gula, Vitalii, ГУЛА, Віталій, Farion, Oleh   +3 more
core   +1 more source

Border Control: The Role of the Microbiome in Regulating Epithelial Barrier Function. [PDF]

Cells
Schreiber F, Balas I, Robinson MJ, Bakdash G.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Justice, legitimacy and political boundaries : the morality of border control [PDF]

The general problem of the morality of borders is to determine what kind of borders liberal democracies ought to have. This in turn raises two particular problems.
Camacho, Enrique
core  

Prototyping a Secure and Usable User Authentication Mechanism for Mobile Passenger ID Devices for Land/Sea Border Control. [PDF]

Sensors (Basel)
Papaioannou M, Zachos G, Mantas G, Panaousis E, Rodriguez J.   +4 more
europepmc   +1 more source