Results 231 to 240 of about 1,273,770 (305)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Without Borders? The Impact of Political Barriers and Land Use on the Animal Health Dynamics and Genetic Structures of Large Game Species in the Carpathian Basin and Surrounding Regions-A Systematic Review. [PDF]

Vet Sci
Bagi Z, Knop R, Tulcan C, Tripon R, Marinaș R, Kusza S.   +5 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Visceral leishmaniasis risk clusters on Brazil's borders: 2013 to 2022. [PDF]

Rev Soc Bras Med Trop
Moreira WDC, Leandro GCW, Ferreira H, Silva RMM, Pureza DYD, Hermes-Uliana C, Moreira NM.   +6 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

<i>Cubilin</i> gene mutation screening in Thai Border Collies using double-mismatch allele-specific and multiplex polymerase chain reaction: Implications for Imerslund-Gräsbeck syndrome. [PDF]

Vet World
Lerdkrai C, Akrimajirachoote N, Phungphosop N.   +2 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Chlorfenapyr-based Insecticide Induces Midgut Damage in the Tomato Leaf Miner Phthorimaea absoluta Meyrick, 1917 (Lepidoptera: Gelechiidae) Larvae. [PDF]

Neotrop Entomol
Salgado FS, Dos Santos Pereira G, Silva LLD, Santos RCD, Martins JLA, da Silva Paes J, Picanço MC, Serrão JE.   +7 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source