Results 101 to 110 of about 239,970 (262)

Estimating Cross-Border Mobility from the Difference in Peak Timing: A Case Study of Poland–Germany Border Regions

Mathematics
Human mobility contributes to the fast spatiotemporal propagation of infectious diseases. During an outbreak, monitoring the infection on either side of an international border is crucial as cross-border migration increases the risk of disease ...
Abhishek Senapati, Adam Mertel, Weronika Schlechte-Welnicz, Justin M. Calabrese   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Antibrush Border Antibody Disease: A Case Series

Kidney Medicine
Antibrush border antibody (ABBA) disease is a rare cause of kidney disease characterized by progressive renal tubular injury associated with immune complex deposition along the basement membranes of the proximal tubule and circulating autoantibodies to ...
Michelle Pengshung, Vivek Charu, Megan L. Troxell, Shreeram Akilesh, Kelly D. Smith, J. Ashley Jefferson   +5 more
doaj   +1 more source

Pathogenesis and epidemiology of border disease.

Annales de recherches veterinaires. Annals of veterinary research, 1987
The pathogenesis of BD virus infection of sheep is reviewed briefly. The most serious consequences occur when susceptible pregnant sheep are infected. The virus crosses the placenta readily and can cause foetal death with resorption, mummification or stillbirths.
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

PARIS/ZNF746 DNA-binding domain deficiency promotes adipose tissue hyperplasia and hepatic lipid accumulation

Scientific Reports
Zinc finger protein 746 (ZNF746), also known as PARKIN-interacting substrate (PARIS), is a KRAB-ZFP family transcriptional repressor implicated in Parkinson’s disease and adipogenesis.
Kazuki Hachiya, Yuhei Mizunoe, Joo-Joo Yang, Yuki Uchida, Hiroto Fukai, Tatsuhiro Esashi, Yuka Nozaki, Seiya Mizuno, Satoru Takahashi, Masaki Kobayashi, Yoshikazu Higami   +10 more
doaj   +1 more source

Disease Without Borders [PDF]

CA: A Cancer Journal for Clinicians, 2005
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Clinicopathologic Features of Antibrush Border Antibody Disease

Kidney International Reports
Introduction: Antibrush border antibody disease (ABBA) is an autoimmune tubulointerstitial kidney disease that primarily affects older individuals and results in progressive kidney failure. It is rare with only 20 reported cases. Here, we describe a case
Joel D. Murphy, Tiffany N. Caza, Clarissa A. Cassol, Aaron Storey, Josephine M. Ambruzs, Christie Boils, Patrick D. Walker, Shree Sharma, Nidia Messias, Randolph Hennigar, Nicole K. Andeen, Christine VanBeek, Matthew Palmer, Lakshna Sankar, Pooja Sanghi, Kumar Dinesh, Lance Dicker, Anatoly Urisman, Christopher P. Larsen   +18 more
doaj   +1 more source

Distribution and Genetic Characterization of Border Disease Virus Circulating in Sardinian Ovine Flocks. [PDF]

Pathogens, 2020
Piras IM, Dei Giudici S, Fadda M, Anfossi AG, Oggiano A, Pittau M, Chessa B.   +6 more
europepmc   +1 more source