Results 51 to 60 of about 1,973,227 (196)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Towards a New Departure in Border Studies? A Comment on the Increasing Talk of Complexity [PDF]
Since the mid-2010s at the latest, there has been discussion of the border as a complex phenomenon, aimed at a more comprehensive and differentiated understanding of b/orderings. However, there seems to be an imprecise use of the term ‘complexity’ in the
WILLE, Christian
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Thinking Borders and Border Thinking
, 2021 Obwohl die Grenz- und Migrationsforschung große Überschneidungen aufweisen, unterscheiden sie sich z.B. hinsichtlich ihrer Erkenntnisinteressen und Theoretisierungen.
WILLE, Christian
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Border(ing)s. A Border-Studies Perspective [PDF]
peer reviewedIn both migration studies and border studies, borders are often unquestioned and taken for granted. Increasingly, however, borders are seen as resulting from or resulting in processes and ‘performing’ as powerful agents.
WILLE, Christian
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Border Violence as Border Deterrence Condensed Analysis of Violent Push-Backs from the Ground [PDF]
, 2020 Thousands of people on the move, travelling through the Balkan route to Europe, are caught in a cycle of structural violence marked by repeated denials of access to asylum procedures, physical attacks from EU border authorities, and collective expulsions.
Sapoch, Jack, Augustova, Karolina
core +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source