Results 31 to 40 of about 25,521 (259)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Depression and borderline personality disorder [PDF]

Medical Journal of Australia, 2012
Borderline personality disorder (BPD) is a serious mental illness characterised by dysregulation of emotions and impulses, an unstable sense of self, and difficulties in interpersonal relationships, often accompanied by suicidal and self-harming behaviour. Major depressive disorder (MDD) commonly co-occurs with BPD. Patients with BPD often present with
Josephine A, Beatson, Sathya, Rao
openaire   +4 more sources

Supporting parents with borderline personality disorder through a parenting group intervention: a randomized controlled trial

Borderline Personality Disorder and Emotion Dysregulation
Background There is a need for a parenting intervention that specifically addresses the concerns for parents with borderline personality disorder (BPD) due to the challenges that these parents experience and the stigma that surrounds parenting with BPD ...
Brin F. S. Grenyer, Charlotte C. van Schie, Dianna R. Bartsch, Laura Cooke-O’Connor, Dominic Kleinig, Kayla R. Steele, Cathy McLeod Everitt   +6 more
doaj   +1 more source

Aberrant computational mechanisms of social learning and decision-making in schizophrenia and borderline personality disorder.

PLoS Computational Biology, 2020
Psychiatric disorders are ubiquitously characterized by debilitating social impairments. These difficulties are thought to emerge from aberrant social inference. In order to elucidate the underlying computational mechanisms, patients diagnosed with major
Lara Henco, Andreea O Diaconescu, Juha M Lahnakoski, Marie-Luise Brandi, Sophia Hörmann, Johannes Hennings, Alkomiet Hasan, Irina Papazova, Wolfgang Strube, Dimitris Bolis, Leonhard Schilbach, Christoph Mathys   +11 more
doaj   +1 more source

The Relationship between Self-Compassion, Perceived Social Support, and Self-esteem with Women's Borderline Personality Symptoms, Mediating Role of Aloneness and Hopelessness

مطالعات روانشناختی, 2021
The study aimed to investigate the relationship between self-compassion, perceived social support, and Self-esteem with borderline personality symptoms mediated by aloneness and hopelessness.
Nasim Rezaie, Farzad Ghaderi, Nahid Akrami   +2 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Some psychiatric comorbidity among patients with substance abuse disorder related to pregabalin

Middle East Current Psychiatry, 2022
Background Pregabalin abuse is increasing worldwide and frequently comorbid with another psychiatric disorders including generalized anxiety, major depression, personality disorders, and suicide.
Abdallah Saad Ibrahim, Reem Hassan Bayomy, Ramadan Abdelbr Hussein, Usama Mahmoud Yousef, Waleed Eleraky Elazab   +4 more
doaj   +1 more source

Auto-vampirism in borderline personality disorder: A case report (tur)

Klinik Psikiyatri Dergisi, 2021
Auto-vampirism is a rare behavioral disorder in which a person sucks her/his own blood. The remarkable finding occurring in psychotic disorders such as schizophrenia but it can be seen in other psychiatric diseases.
Aslı Kazğan, Sevler Yildiz, Sevda Korkmaz, Murad Atmaca   +3 more
doaj   +1 more source

Personality Traits and Borderline Personality Disorder

Journal of International Scientific Researches, 2016
The people with Borderline Personality Disorder (BPD) show pathological personality traits in three of the five domains (APA 2013). In addition to diagnostic criteria for BPD, described by Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the dimensional model of personality disorder, based on five-factor model of personality, seems to ...
TAHIROVIC, Senija, BAJRIC, Adela
openaire   +3 more sources

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source