Results 221 to 230 of about 14,053 (266)

Boron nanodrugs for boron neutron capture therapy

Applied Radiation and Isotopes
Boron neutron capture therapy (BNCT) is a promising therapeutic method for malignant tumors, capable of selectively killing tumor cells through nuclear reactions at the single-cell level without damaging surrounding normal cells. With the rapid development of nano-delivery systems in recent years, boron nanodrugs have improved the efficiency of intra ...
Jiaxin, Wan, Linwen, Lv, Yanan, Chang, Juan, Li, Gengmei, Xing, Kui, Chen   +5 more
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Overview of Boron Neutron Capture Therapy in 2022

Cancer Biotherapy and Radiopharmaceuticals, 2023
In April 2022, the National Cancer Institute of the United States organized a 3-day seminar, dedicated to boron neutron capture therapy (BNCT). This short article summarizes a presentation from that event, which is intended to provide an overview of activities currently underway worldwide to make BNCT available for patient treatments.
Wolfgang A.G. Sauerwein, Miha Ulčar
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Boron Compounds for Neutron Capture Therapy

1989
There have been two main approaches to the development of boron compounds for neutron capture therapy (BNCT). One has involved the synthesis of boronated analogues of organic structures which possess a high degree of selectivity for neoplastic cells. These include amino acids, nucleic acid precusors, porphyrins and promazines.
F, Alam, A H, Soloway, B V, Bapat, R F, Barth, D M, Adams   +4 more
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Boron neutron capture therapy for malignant gliomas

Annals of Medicine, 2000
Boron neutron capture therapy (BNCT) represents a promising modality for a relatively selective radiation dose delivery to the tumour tissue. Boron-10 nuclei capture slow 'thermal' neutrons preferentially and, upon capture, promptly undergo 10B(n,alpha)7Li reaction.
A Z, Diaz, J A, Coderre, A D, Chanana, R, Ma   +3 more
exaly   +3 more sources

The role of boron MRI in boron neutron capture therapy

Journal of Neuro-Oncology, 1997
Boron magnetic resonance imaging (MRI) and spectroscopy (MRS) are being developed for use in boron neutron capture therapy (BNCT). With continued development, boron MRI may be used to locate BNCT agents in vivo, evaluate the pharmacokinetics of BNCT agents, and aid in treatment planning.
G W, Kabalka, C, Tang, P, Bendel
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Boronated Thymidine Analogues for Boron Neutron Capture Therapy

Nucleosides, Nucleotides and Nucleic Acids, 2006
Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described.
B T S, Thirumamagal, Jayaseharan, Johnsamuel, Guirec Y, Cosquer, Youngjoo, Byun, Junhua, Yan, Sureshbabu, Narayanasamy, Werner, Tjarks, Rolf F, Barth, Ashraf S, Al-Madhoun, Staffan, Eriksson   +9 more
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Boron neutron capture therapy.

The British Journal of Radiology, 1997
mal or epithermal neutron irradiation. Naturallythe Petten High Flux Reactor Centre, Holland and occurring 10B has a very high affinity for thermal at the University of Helsinki, Finland. Other neutrons, having a thermal neutron cross-section European Centres, including the UK group in of 3838 barns for the 10B(n, a) 7Li reaction.
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Optimization of Boron and Neutron Delivery for Neutron Capture Therapy

Pigment Cell Research, 1989
A number of groups in the United States have received funding that will permit evaluation of the clinical efficacy of the neutron capture therapy (NCT) procedure. Various reactors are being modified to allow the construction of an epithermal neutron beam.At the Brookhaven Medical Research Reactor (BMRR), the patient irradiation facility is being ...
R G, Fairchild, D N, Slatkin, J A, Coderre, P L, Micca, B H, Laster, S B, Kahl, P, Som, I, Fand, F, Wheeler   +8 more
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Boron neutron capture therapy of a rat glioma

Neurosurgery, 1990
The purpose of the present study was to utilize a well-established rat glioma to evaluate boron neutron capture therapy for the treatment of malignant brain tumors. Boron-10 (10B) is a stable isotope which, when irradiated with thermal neutrons, produces a capture reaction yielding high linear energy transfer particles (10B + 1nth----[11B]----4He(alpha)
N R, Clendenon, R F, Barth, W A, Gordon, J H, Goodman, F, Alam, A E, Staubus, C P, Boesel, A J, Yates, M L, Moeschberger, R G, Fairchild   +9 more
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Boron-neutron capture therapy in relation to immunotherapy

Acta Neurochirurgica, 1978
The essential feature of tumour therapy rests upon host-tumour interaction. To achieve therapeutic effects, a prerequisite to immunotherapy is the reduction of tumour cells in the host's body. Such measures should not be immunosuppressive. Cytotoxic chemotherapy is not appropriate in this regard.
H, Hatanaka, K, Amano, S, Kamano, H, Fankhauser, T, Hanamura, K, Sano   +5 more
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