Results 241 to 250 of about 960,199 (321)

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

The Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor, Miguel Martin‐Aragon Baudel, Eric Pereira da Silva, Johannes W. Hell, Madeline Nieves‐Cintron, Manuel F. Navedo   +5 more
wiley   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

Functional expression of inwardly rectifying and ATP‐sensitive potassium channels in human pulmonary artery smooth muscle and endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Inwardly rectifying (Kir2) and ATP‐sensitive (KATP) potassium channels are functionally expressed in human pulmonary artery endothelial and smooth muscle cells. The schematic illustrates how Kir2‐ and KATP‐mediated K+ efflux contributes to VM regulation and pulmonary vascular tone.
Bianca Barreira, Daniel Morales‐Cano, Laura Moreno, Beatriz de Olaiz, Rui Adão, Angel Cogolludo, Francisco Perez‐Vizcaino, Maria Sancho   +7 more
wiley   +1 more source

Myosin 7a is required for maintaining the transducing stereocilia and for force transmission to the MET channel during cochlear hair cell development

The Journal of Physiology, EarlyView.
Abstract figure legend Developmental changes in the hair‐bundle structure of outer hair cells (OHCs) and inner hair cells (IHCs) were examined in control and shaker‐1 mutant (Myo7aSh1/Sh1) mice, which carry a spontaneous missense mutation in the Myo7a gene that produces a non‐functional MYO7A protein.
Anna Underhill, Samuel Webb, Fiorella C. Grandi, Adam J. Carlton, Jing‐Yi Jeng, Stuart L. Johnson, Corné J. Kros, Walter Marcotti   +7 more
wiley   +1 more source

Distinct developmental dynamics of opposing persistent currents shape motoneuron firing during motor maturation of zebrafish

The Journal of Physiology, EarlyView.
Abstract figure legend During the first few days of development, zebrafish acquire the ability to produce increasingly refined movements that rely progressively less on the activity of primary motoneurons. At the same time, primary motoneurons undergo functional maturation, becoming increasingly capable of repetitive firing.
Stephanie F. Gaudreau, Tuan V. Bui
wiley   +1 more source

Atmospheric Deposition of Organic Pollutants: A Comprehensive Review of Sampling and Analytical Methodologies

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Atmospheric deposition of organic pollutants plays a crucial role in the transport and fate of contaminants in the environment, with implications for ecosystem health and human exposure. Persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs) and microplastics are increasingly recognized as transboundary threats due to ...
Iva Smoljo, Gordana Mendaš, Gordana Pehnec   +2 more
wiley   +1 more source

Sex‐Specific doublesex Regulation Targeting the Color‐Patterning Gene h Underlies the Evolution of Wing Sexual Dimorphism in the Harlequin Ladybug Harmonia axyridis

Evolution &Development, Volume 28, Issue 1, March 2026.
doublesex regulates sexual dimorphism in elytral color patterns of Harmonia axyridis by downregulating the color patterning gene h in males. This regulatory link diverged in derived color morphs, coinciding with the loss of sex‐specific elytral color patterns.
Soichi Yeki, Kagayaki Kato, Shinichi Morita, Kenji Shimomura, Teruyuki Niimi, Norihide Hinomoto, Takaaki Daimon, Toshiya Ando   +7 more
wiley   +1 more source

Electrochemical Degradation of Perfluoroalkyl Sulfonates via Sulfonate to Carboxylate Conversion

Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.
We demonstrate a novel approach for the degradation of perfluoroalkyl sulfonic acids (PFSAs) involving a controlled, electromediated, sulfonate‐to‐carboxylate headgroup conversion. We apply this method to shorter chain PFSAs and provide key mechanistic insights that contribute to a broader understanding of the molecular pathways underlying pollutant ...
Stella A. Fors, Richard J. Monsky, Emily R. Mahoney, Christian A. Malapit, William R. Dichtel   +4 more
wiley   +2 more sources

SALT OVERLY SENSITIVE 1 Na+/H+ Exchanger Operates in Mature Root Zone and Is a Major Contributor to Root Na+ Exclusion During Shoot‐to‐Root Na+ Recirculation

Plant, Cell &Environment, Volume 49, Issue 3, Page 1650-1660, March 2026.
ABSTRACT The Na+/H+ antiporter SALT OVERLY SENSITIVE 1 (SOS1) is a key component of Na+ exclusion and plant salt tolerance. Although previous studies have suggested that SOS1 functions in both the root apex and mature root zone, their contributions remain unclear due to limited methodological resolution and originated mostly from transcriptional ...
Tomoki Nagata, Ryohei Sugita, Takaaki Ogura, Mio Nagoya, Natsuko I. Kobayashi, Muhammad B. Gill, Lana Shabala, Tomoko M. Nakanishi, Sergey Shabala, Keitaro Tanoi   +9 more
wiley   +1 more source

Human Dorsal Root Ganglia Neuronal Cell Line to Study Nociceptive Signaling: A New Pipeline for Pain Therapy

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
The nociceptive properties of differentiated human HD10.6 cells were characterized by multiple approaches (A). Peripheral sensitization was induced within HD10.6 cells in response to an inflammatory cocktail (B), modeling nociceptors in a chronic pain state.
Sara A. Dochnal, Yixing Du, Daniella Bandari, Kaue Franco Malange, Jack Bryant, Julia Borges Paes Lemes, Abby Whitford, Anna R. Cliffe, Prashant Mali, Kim Dore, Yury I. Miller, Tony L. Yaksh   +11 more
wiley   +1 more source