Results 41 to 50 of about 903,590 (266)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Numerical simulation of flow-sediment dynamics in wave-current bottom boundary layer: III: simulation of high concentration near the bottom

Shui kexue jinzhan, 2019
Studies of the high concentration layer (HCL) have great theoretical and practical significance in the protection and utilization of estuarial and coastal areas.
ZUO Liqin, LU Yongjun, ZHU Hao
doaj   +1 more source

Gravity current down a steeply inclined slope in a rotating fluid [PDF]

Annales Geophysicae, 1997
The sinking of dense water down a steep continental slope is studied using laboratory experiments, theoretical analysis and numerical simulation.
G. I. Shapiro, A. G. Zatsepin
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Unraveling the Enrichment Mechanisms of Rare Earth Elements in Deep‐Sea Sediments: An Environmental Magnetic Perspective

Geophysical Research Letters
Deep‐sea rare earth elements and yttrium (REY)‐rich sediments have attracted considerable attention since their discovery in 2011. However, the environmental factors controlling REY enrichment remain poorly understood, largely because paleoceanographic ...
Xiangfeng He, Jianxing Liu, Dongjie Bi, Yamin Zhang, Mu Huang, Miao Yu, Fengdeng Shi, Jianhua Gao, Xuefa Shi   +8 more
doaj   +1 more source

Characterization and mechanism of resuspension events induced by internal tides at the toe of Shenhu canyon

Applied Ocean Research
Understanding sediment resuspension in deep-sea (primarily deeper than 1000 m) environments is critical for environmental impact assessments and engineering planning.
Cong Hu, Hui Wang, Chunsheng Ji, Xuezhi Feng, Zhaoyang Tian, Yonggang Jia   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Dynamics of bottom currents in a small lake1 [PDF]

Limnology and Oceanography, 1987
The dynamics of bottom currents in Baldeggersee, Switzerland, were investigated with a specially designed recording current meter sensitive to current velocities of 0.3–2.5 cm s−1. Supporting information was obtained from thermistor‐chain temperature recordings and from records of atmospheric boundary‐layer parameters measured in the center of the lake.
U. Lemmin, D. M. Imboden
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source